Detail publikace

In-silico characterization of human metallothionein (MT-1E) and its role in prevention and therapy of bladder cancer with dietary agents

ROY, S. PROVAZNÍK, I.

Originální název

In-silico characterization of human metallothionein (MT-1E) and its role in prevention and therapy of bladder cancer with dietary agents

Český název

In-silico characterization of human metallothionein (MT-1E) and its role in prevention and therapy of bladder cancer with dietary agents

Anglický název

In-silico characterization of human metallothionein (MT-1E) and its role in prevention and therapy of bladder cancer with dietary agents

Typ

článek ve sborníku

Jazyk

en

Originální abstrakt

Metallothioneins (MT) are a group of low-molecular weight, cysteine rich intracellular proteins, which are encoded by a family of genes containing at least 10 functional isoforms in human. This includes MT-I, MT-II, MT-III and MT-IV. The expression and induction of these proteins have been associated with protection against DNA damage, oxidative stress and apoptosis. A number of studies have shown an increased expression of MT in various human tumors of the breast, colon, kidney, liver, lung, nasopharynx, ovary, prostate, salivary gland, testes, thyroid and urinary bladder. In the current study, an effort has been made to characterize MT-1E protein isoform in humans structurally and functionally through in-silico approaches. The study is extended to comprehend the effect of dietary agents found in fruits and vegetables that can keep a check on bladder cancer. The finding shows that dietary agent silybinin (Silybummarianum L.) and catechin (Camellia sinensis) provided insights in checking bladder cancer.

Český abstrakt

Metallothioneins (MT) are a group of low-molecular weight, cysteine rich intracellular proteins, which are encoded by a family of genes containing at least 10 functional isoforms in human. This includes MT-I, MT-II, MT-III and MT-IV. The expression and induction of these proteins have been associated with protection against DNA damage, oxidative stress and apoptosis. A number of studies have shown an increased expression of MT in various human tumors of the breast, colon, kidney, liver, lung, nasopharynx, ovary, prostate, salivary gland, testes, thyroid and urinary bladder. In the current study, an effort has been made to characterize MT-1E protein isoform in humans structurally and functionally through in-silico approaches. The study is extended to comprehend the effect of dietary agents found in fruits and vegetables that can keep a check on bladder cancer. The finding shows that dietary agent silybinin (Silybummarianum L.) and catechin (Camellia sinensis) provided insights in checking bladder cancer.

Anglický abstrakt

Metallothioneins (MT) are a group of low-molecular weight, cysteine rich intracellular proteins, which are encoded by a family of genes containing at least 10 functional isoforms in human. This includes MT-I, MT-II, MT-III and MT-IV. The expression and induction of these proteins have been associated with protection against DNA damage, oxidative stress and apoptosis. A number of studies have shown an increased expression of MT in various human tumors of the breast, colon, kidney, liver, lung, nasopharynx, ovary, prostate, salivary gland, testes, thyroid and urinary bladder. In the current study, an effort has been made to characterize MT-1E protein isoform in humans structurally and functionally through in-silico approaches. The study is extended to comprehend the effect of dietary agents found in fruits and vegetables that can keep a check on bladder cancer. The finding shows that dietary agent silybinin (Silybummarianum L.) and catechin (Camellia sinensis) provided insights in checking bladder cancer.

Klíčová slova

bladder cancer; dietary agents; metallothioneins; molecular docking

Rok RIV

2014

Vydáno

01.06.2014

Nakladatel

IEEE

Místo

New York

ISBN

978-1-4799-4435-4

Kniha

2014 IEEE 27th International Symposium on Computer-Based Medical Systems

Strany od

469

Strany do

470

Strany počet

2

BibTex


@inproceedings{BUT107771,
  author="Sudeep {Roy} and Ivo {Provazník}",
  title="In-silico characterization of human metallothionein (MT-1E) and its role in prevention and therapy of bladder cancer with dietary agents",
  annote="Metallothioneins (MT) are a group of low-molecular weight, cysteine rich intracellular proteins, which are encoded by a family of genes containing at least 10 functional isoforms in human. This includes MT-I, MT-II, MT-III and MT-IV. The expression and induction of these proteins have been associated with protection against DNA damage, oxidative stress and apoptosis. A number of studies have shown an increased expression of MT in various human tumors of the breast, colon, kidney, liver, lung, nasopharynx, ovary, prostate, salivary gland, testes, thyroid and urinary bladder. In the current study, an effort has been made to characterize MT-1E protein isoform in humans structurally and functionally through in-silico approaches. The study is extended to comprehend the effect of dietary agents found in fruits and vegetables that can keep a check on bladder cancer. The finding shows that dietary agent silybinin (Silybummarianum L.) and catechin (Camellia sinensis) provided insights in checking bladder cancer.",
  address="IEEE",
  booktitle="2014 IEEE 27th International Symposium on Computer-Based Medical Systems",
  chapter="107771",
  doi="10.1109/CBMS.2014.94",
  howpublished="electronic, physical medium",
  institution="IEEE",
  year="2014",
  month="june",
  pages="469--470",
  publisher="IEEE",
  type="conference paper"
}