Detail předmětu

Advanced Molecular Medicine

CEITEC VUT-DSAMolMAk. rok: 2019/2020

Jazyk výuky

angličtina

Počet kreditů

3

Zajišťuje ústav

Lékařská fakulta (LF MU)

Výsledky učení předmětu

Students will be exposed to the recent advances in the field of cancer biology including methodological approaches, novel concepts in the biology of heart and vision, and also regenerative medicine. They will understand the opened questions in the field, and the further directions with implications for therapy of patients. They will to learn and discuss how molecular biology contributes to disease treatment and regenerative medicine. They will have in-depth discussion with experts in the field.

Plánované vzdělávací činnosti a výukové metody

lectures, class discussion, group projects, and presentations

Osnovy výuky



1. CANCER: Cancer Genomics to Targeted Therapies/Precision Cancer Medicine (NGS)
2. CANCER: Emerging Methods for Functional Genomic Analysis
3. CANCER: Rethinking Immunotherapeutic approaches in Cancer
4. CANCER: Non-coding RNAs in Cancer
5. CANCER: Microenvironment interactions in Cancer
6. CANCER: Advances in Patient-Derived Xenograft Modeling
7. CANCER: New Clinical Trial Design for Targeted Therapies and Use of Liquid Biopsies
8. CANCER: Biologic and Clinical Significance of Intratumoral Heterogeneity
9. CANCER: Impact of the Microbiome
10. CANCER: Cancer Modeling with CRISPR
11. CANCER: Advances in Cancer/Neo-antigen Vaccines
12. CANCER: Single-Cell Analysis of the Epigenome and Transcriptome
13. CANCER: Extracellular Vesicles
14. CANCER: Genomic/Functional Screens to Predict Response/Resistance
15. HEART: Regulation of cardiomyocyte contractility
16. HEART: Molecular changes in cardiomyopathies and therapeutic interventions
17. HEART: Molecular mechanisms of mechano-sensing
18. HEART: Biochemical and structural changes of extracellular matrix during remodelling
19. HEART: 2D and 3D in vitro models of cardiac tissue
20. HEART: Regeneration of the heart
21. REGENERATIVE MEDICINE: Cell reprogramming - change of cell identity
22. REGENERATIVE MEDICINE: Application potential of pluripotent stem cells
23. REGENERATIVE MEDICINE AND VISION: Modeling vision in vitro – retinal organoids and generation of cells for vision therapy
24. REGENERATIVE MEDICINE: Modelling of neural development using pluripotent stem cells
25. REGENERATIVE MEDICINE: 3D cell culture for organoids and organs-on-chip
26. REGENERATIVE MEDICINE: Neuro-regeneration and mini-brains for neurodegenerative diseases in vitro

Učební cíle

The main objective is to discuss novel concepts in CANCER BIOLOGY (approx. 2 days), BASIC MOLECULAR MECHANISMS IN THE REGULATION OF HEART BIOLOGY and VISION (approx. half day), AND REGENERATIVE MEDICINE (approx. half day). The students will present and discuss selected articles relevant for the topic. The course will be thought by several experts in the field and recent high-profile articles and discoveries will be discussed:
- orientation in the most recent advances in the pathogenesis and targeted therapy in cancer, focus on selecting therapy based on molecular aberrations, novel design of clinical trials (basket/umbrella trials, n=1 trials)
- modern technics affecting the study and therapy in oncology, especially Crispr and Next-generation sequencing (NGS), single cell analysis
- novel concepts in immunotherapy such as CAR-T cell and check-point inhibitors, and their position in oncology
- role of tumor microenvironment on the progression and therapy of diseases
- regenerative medicine of human heart and vision
- neurodegenerative disease biology, and possibilities of studies with neuronal precursors derived from embryonic stem cells, preparation of mini-brains

Základní literatura

Presentations from the course (EN)
Scientific articles from the course (EN)