Course detail

General Toxicology

FCH-BCA_OBTAcad. year: 2017/2018

The science of toxicology. Terminology of toxicology, History. The explanation of the relation of dose - effec, mechamism of toxic effects, factors influencing toxic effects, characteristics of of toxic effects, basic principles. The chemical compounds interaction. Mechanism of chemical compounds penetrating to organism. Toxicologic kinetice (primary contact, absorption, transport, excrection). The biotransformation of toxic compounds, factors influencing the biotransformation. The causation of demage of cells, tissues, organism and species levels. The main types of toxic effects. The evaluation of toxicity. The summary of the toxicology of inorganic and organic elements, compounds. The overview of therapy, antidots. The classification of chemical compounds in CZ and EU, actual legislative. The source of information, the information system of toxicology.

Learning outcomes of the course unit

Students will obtained new knowledge, understanding and knowledge in the following areas
1. Students will be able to use the terms in toxicology and other chemical sectors (environmental chemistry, ecotoxicology, etc.)
2. Students will obtain the knowledge of mechanisms of toxic effects on organisms and they will know the different types of toxic effects.
3. Students will understand the influence of factors (internal and external) on the toxicity of substances.
4. Students gain knowledge and experience toxic effects of inorganic and organic substances on the organism.
5. Students will understand the current legislative and regulatory documents defining the handling of chemicals.

Prerequisites

Basic principles of chemistry, biology and ecology.

Co-requisites

Not applicable.

Recommended optional programme components

Not applicable.

Recommended or required reading

Tichý, M., Toxikologie pro chemiky. Universita Karlova, Praha, 2002 (CS)
Lullman, H., Mohr, K., Wehling, M., Farmakologie a toxikologie, Grada vicenum, 2002 (CS)
Walker, C.H., Principles of ecotoxicology, Ed. Taylor and Francis, London, 2001 (CS)
Timbrell, J. A., Introduction to Toxicology. Taylor and Francis, London, 1995 (CS)
Matrka M., Rusek V., Průmyslová toxikologie, Úvod do obecné a speciální toxikologie Univerzita Pardubice, 1994 (CS)
Doležalová: Elearningové studijní opory, https://www.vutbr.cz/elearning/course (CS)
http://toxnet.nlm.nih.gov/ (CS)
http://www.knovel.com/web/portal/browse/display?_EXT_KNOVEL_DISPLAY_bookid=235Casarett and Doull's Toxicology - The Basic Science of Poisons, 5 (CS)

Planned learning activities and teaching methods

The course uses teaching methods in form of Lecture - 2 teaching hours per week. The e-learning system (LMS Moodle) is available to teachers and students.

Assesment methods and criteria linked to learning outcomes

Test in the form of written test along with the oral exam in the range of lectures and recommended literature

Language of instruction

Czech

Work placements

Not applicable.

Course curriculum

1. The term toxicology within the context of natural sciences, basic definitions, history
2. Toxic effect, factors influenced on toxic effect.
3. Characteristics of toxic effects.
4. Interaction toxic agents and possible damages of organisms on the level of cell, organs, organism, species.
5. Mechanism of intragression of toxic agents into body.

Aims

The aim is to provide and explain the basic concepts in toxicology, to clarify the mechanisms of the effects of pollutants and toxic chemicals at different levels, to explain the factors affecting toxicity. In this course students will get acquainted with the toxic effects of selected inorganic and organic compounds and substances, current legislation and defining documents dealing with chemicals and safety.

Specification of controlled education, way of implementation and compensation for absences

Attendance at lectures is recommended, but not controlled.
An integral part of teaching and combined form of teaching is a e-learning tutorial course, divided into blocks, within which are available to students learning support including electronic textbooks, presentations, lectures, and other complementary materials.
For students in combined form of study are organized consultations on the topics for full-time students.
Consultations are also provided to full-time students on request.

Classification of course in study plans

  • Programme BPCP_CHCHT Bachelor's

    branch BPCO_SCH , 1. year of study, summer semester, 2 credits, compulsory

  • Programme BKCP_CHCHT Bachelor's

    branch BKCO_SCH , 1. year of study, summer semester, 2 credits, compulsory

  • Programme BPCP_CHCHT Bachelor's

    branch BPCO_CHTOZP , 1. year of study, summer semester, 2 credits, compulsory

  • Programme BKCP_CHCHT Bachelor's

    branch BKCO_CHTOZP , 1. year of study, summer semester, 2 credits, compulsory

  • Programme BPCP_CHCHT Bachelor's

    branch BPCO_CHMN , 1. year of study, summer semester, 2 credits, compulsory
    branch BPCO_CHM , 1. year of study, summer semester, 2 credits, compulsory

  • Programme BKCP_CHCHT Bachelor's

    branch BKCO_CHM , 1. year of study, summer semester, 2 credits, compulsory

  • Programme BPCP_CHTP Bachelor's

    branch BPCO_BT , 1. year of study, summer semester, 2 credits, compulsory

  • Programme BKCP_CHTP Bachelor's

    branch BKCO_BT , 1. year of study, summer semester, 2 credits, compulsory
    branch BKCO_PCH , 1. year of study, summer semester, 2 credits, compulsory

  • Programme BPCP_CHTP Bachelor's

    branch BPCO_CHP , 1. year of study, summer semester, 2 credits, compulsory

  • Programme CKCP_CZV lifelong learning

    branch CKCO_CZV , 1. year of study, summer semester, 2 credits, compulsory

Type of course unit

 

Lecture

26 hours, optionally

Teacher / Lecturer