Publication detail
Comparison and evaluation of indicator dilution models for bolus of ultrasound contrast agents
HARABIŠ, V. KOLÁŘ, R. MÉZL, M. JIŘÍK, R.
Original Title
Comparison and evaluation of indicator dilution models for bolus of ultrasound contrast agents
English Title
Comparison and evaluation of indicator dilution models for bolus of ultrasound contrast agents
Type
journal article in Web of Science
Language
en
Original Abstract
Dynamic contrast-enhanced ultrasound (DCE-US) imaging is a promising diagnostic method, which enables the evaluation of tissue perfusion via different parameters. The mean transit time and time-to-peak parameters are the main time parameters and their values depend on the model used for the approximation of the noisy perfusion curves. In this paper, we described a new comparison of different perfusion models using a tissue mimicking phantom. The following models were compared: log-normal, lagged, Erlang, Gamma and the local density random walk model. We discovered that the mean-square error is not the best criterion for model evaluation. More important is the comparison between the estimated time perfusion parameters and the physical parameters of the developed tissue mimicking phantom. Based on the statistical analysis, we can suggest that for the DCE-US perfusion analysis more models should be used, excluding the log-normal model, which gives the highest error of mean transit time value.
English abstract
Dynamic contrast-enhanced ultrasound (DCE-US) imaging is a promising diagnostic method, which enables the evaluation of tissue perfusion via different parameters. The mean transit time and time-to-peak parameters are the main time parameters and their values depend on the model used for the approximation of the noisy perfusion curves. In this paper, we described a new comparison of different perfusion models using a tissue mimicking phantom. The following models were compared: log-normal, lagged, Erlang, Gamma and the local density random walk model. We discovered that the mean-square error is not the best criterion for model evaluation. More important is the comparison between the estimated time perfusion parameters and the physical parameters of the developed tissue mimicking phantom. Based on the statistical analysis, we can suggest that for the DCE-US perfusion analysis more models should be used, excluding the log-normal model, which gives the highest error of mean transit time value.
Keywords
Ultrasonography, Contrast agent, Perfusion analysis, Perfusion models
RIV year
2013
Released
26.01.2013
ISBN
0967-3334
Periodical
PHYSIOLOGICAL MEASUREMENT
Year of study
34
Number
2
State
GB
Pages from
151
Pages to
162
Pages count
12
Documents
BibTex
@article{BUT97515,
author="Vratislav {Harabiš} and Radim {Kolář} and Martin {Mézl} and Radovan {Jiřík}",
title="Comparison and evaluation of indicator dilution models for bolus of ultrasound contrast agents",
annote="Dynamic contrast-enhanced ultrasound (DCE-US) imaging is a promising diagnostic method, which
enables the evaluation of tissue perfusion via different parameters. The mean transit time and
time-to-peak parameters are the main time parameters and their values depend on the model used for
the approximation of the noisy perfusion curves. In this paper, we described a new comparison of
different perfusion models using a tissue mimicking phantom. The following models were compared:
log-normal, lagged, Erlang, Gamma and the local density random walk model. We discovered that the
mean-square error is not the best criterion for model evaluation. More important is the comparison
between the estimated time perfusion parameters and the physical parameters of the developed tissue
mimicking phantom. Based on the statistical analysis, we can suggest that for the DCE-US perfusion
analysis more models should be used, excluding the log-normal model, which gives the highest error
of mean transit time value.",
chapter="97515",
number="2",
volume="34",
year="2013",
month="january",
pages="151--162",
type="journal article in Web of Science"
}