Publication detail

Structure, Polymorphisms and Electrochemistry of Mammalian Metallothioneins – A Review

ŠKUTKOVÁ, H. BABULA, P. STIBOROVÁ, M. ECKSCHLAGER, T. TRNKOVÁ, L. PROVAZNÍK, I. HUBÁLEK, J. KIZEK, R. ADAM, V.

Original Title

Structure, Polymorphisms and Electrochemistry of Mammalian Metallothioneins – A Review

English Title

Structure, Polymorphisms and Electrochemistry of Mammalian Metallothioneins – A Review

Type

journal article in Web of Science

Language

en

Original Abstract

Mammalian metallothioneins (MTs) are cysteine-rich low-molecular mass proteins with numerous functions including toxic metal detoxification, as a metal chaperone and maintenance of metal ion homeostasis. Four major isoforms (MT-1 through MT-4) have been identified in mammals. In this review, the functions of the isoforms are summarized. Moreover, polymorphisms of MTs genes and their connection with cancerogenesis and cancer diagnostics are described. The interesting properties of MTs are closely related with structure, which can be studied by modern bioinformatics approaches and electrochemical methods. The advantages of the mentioned approaches and methods are discussed.

English abstract

Mammalian metallothioneins (MTs) are cysteine-rich low-molecular mass proteins with numerous functions including toxic metal detoxification, as a metal chaperone and maintenance of metal ion homeostasis. Four major isoforms (MT-1 through MT-4) have been identified in mammals. In this review, the functions of the isoforms are summarized. Moreover, polymorphisms of MTs genes and their connection with cancerogenesis and cancer diagnostics are described. The interesting properties of MTs are closely related with structure, which can be studied by modern bioinformatics approaches and electrochemical methods. The advantages of the mentioned approaches and methods are discussed.

Keywords

Metallothionein; Isoforms; Bioinformatics; Data Analysis; Phylogeny; DNA Sequencing; Electrochemistry; Voltammetry; Brdicka Reaction; Peak H

RIV year

2012

Released

01.12.2012

Pages from

12415

Pages to

12431

Pages count

16

BibTex


@article{BUT96584,
  author="Helena {Škutková} and Petr {Babula} and Marie {Stiborová} and Tomáš {Eckschlager} and Libuše {Trnková} and Ivo {Provazník} and Jaromír {Hubálek} and René {Kizek} and Vojtěch {Adam}",
  title="Structure, Polymorphisms and Electrochemistry of Mammalian Metallothioneins – A Review",
  annote="Mammalian  metallothioneins (MTs) are cysteine-rich low-molecular mass proteins with numerous 
functions  including toxic metal detoxification, as a metal chaperone and maintenance of metal ion 
homeostasis. Four major isoforms (MT-1 through MT-4) have been identified in mammals.  In this 
review, the functions of the isoforms are summarized. Moreover, polymorphisms of MTs genes and 
their connection with cancerogenesis and cancer diagnostics are described. The interesting properties 
of MTs are closely related with structure, which can be studied by modern bioinformatics approaches 
and electrochemical methods. The advantages of the mentioned approaches and methods are discussed.",
  chapter="96584",
  number="7",
  volume="2012",
  year="2012",
  month="december",
  pages="12415--12431",
  type="journal article in Web of Science"
}