Publication detail

Mammalian metallothioneins: properties and functions

BABULA, P. MASAŘÍK, M. ADAM, V. ECKSCHLAGER, T. STIBOROVÁ, M. TRNKOVÁ, L. ŠKUTKOVÁ, H. PROVAZNÍK, I. HUBÁLEK, J. KIZEK, R.

Original Title

Mammalian metallothioneins: properties and functions

English Title

Mammalian metallothioneins: properties and functions

Type

journal article in Web of Science

Language

en

Original Abstract

Metallothioneins (MT) are a family of ubiquitous proteins, whose role is still discussed in numerous papers, but their afinity to some metal ions is undisputable. These cysteine-rich proteins are connected with antioxidant activity and protective efects on biomolecules against free radicals, especially reactive oxygen species. In this review, the connection between zinc( II ) ions, reactive oxygen species, heavy metal ions and metallothioneins is demonstrated with respect to effect of these proteins on cell proliferation and a ossible negative role in resistance to heavy metal-based and non-heavy metal-based drugs.

English abstract

Metallothioneins (MT) are a family of ubiquitous proteins, whose role is still discussed in numerous papers, but their afinity to some metal ions is undisputable. These cysteine-rich proteins are connected with antioxidant activity and protective efects on biomolecules against free radicals, especially reactive oxygen species. In this review, the connection between zinc( II ) ions, reactive oxygen species, heavy metal ions and metallothioneins is demonstrated with respect to effect of these proteins on cell proliferation and a ossible negative role in resistance to heavy metal-based and non-heavy metal-based drugs.

Keywords

metallothionein, cell proliferation, free radicals

RIV year

2012

Released

01.08.2012

Publisher

Royal Society of Chemistry

Location

UK

Pages from

739

Pages to

750

Pages count

12

BibTex


@article{BUT93281,
  author="Petr {Babula} and Michal {Masařík} and Vojtěch {Adam} and Tomáš {Eckschlager} and Marie {Stiborová} and Libuše {Trnková} and Helena {Škutková} and Ivo {Provazník} and Jaromír {Hubálek} and René {Kizek}",
  title="Mammalian metallothioneins: properties and functions",
  annote="Metallothioneins (MT) are a family of ubiquitous proteins, whose role is still discussed in numerous papers, but their afinity to some metal ions is undisputable. These cysteine-rich proteins are connected with antioxidant activity and protective efects on biomolecules against free radicals, especially reactive oxygen species. In this review, the connection between zinc( II ) ions, reactive oxygen species, heavy metal ions and metallothioneins is demonstrated with respect to effect of these proteins on cell proliferation and a ossible negative role in resistance to heavy metal-based and non-heavy metal-based drugs.",
  address="Royal Society of Chemistry",
  chapter="93281",
  doi="10.1039/c2mt20081c",
  institution="Royal Society of Chemistry",
  number="1",
  volume="4",
  year="2012",
  month="august",
  pages="739--750",
  publisher="Royal Society of Chemistry",
  type="journal article in Web of Science"
}