Publication detail

Aerosol Transport in a Model of Human Lungs

LÍZAL, F. JEDELSKÝ, J. LIPPAY, J. HALASOVÁ, T. MRAVEC, F. JÍCHA, M.

Original Title

Aerosol Transport in a Model of Human Lungs

English Title

Aerosol Transport in a Model of Human Lungs

Type

conference paper

Language

en

Original Abstract

Complex flow structures emerging in human lungs significantly affect deposition of inhaled particles. Therefore flow measurements alongside with deposition measurements have to be performed on the same model geometry. Amount of deposited aerosol particles in different regions of lungs could be measured by several methods. Gamma detection of radioactive tagged particles is subjected to strict regulations and is expensive; gravimetry and fluorometry are thus preferred in current studies. Novel methodology for fluorometric measurement of aerosol transport in models of human lungs was developed. Some previously published experiments were performed using condensation of di(2-ethylhexyl) sebacate (DEHS) vapours on fluorescein nuclei. Their authors assumed that fluorescein is necessary for generation of fluorescent particles and they neglected possible fluorescence of DEHS itself. Our analysis of DEHS characteristics indicated that DEHS fluorescence could be detected apart in sufficient rate to evaluate aerosol deposition. Consequently experiments in standard setup of condensation monodisperse aerosol generator with sodium chloride nuclei instead of fluorescein were performed. Results demonstrating applicability and limitations of DEHS particles for fluorometric deposition measurements are presented and discussed.

English abstract

Complex flow structures emerging in human lungs significantly affect deposition of inhaled particles. Therefore flow measurements alongside with deposition measurements have to be performed on the same model geometry. Amount of deposited aerosol particles in different regions of lungs could be measured by several methods. Gamma detection of radioactive tagged particles is subjected to strict regulations and is expensive; gravimetry and fluorometry are thus preferred in current studies. Novel methodology for fluorometric measurement of aerosol transport in models of human lungs was developed. Some previously published experiments were performed using condensation of di(2-ethylhexyl) sebacate (DEHS) vapours on fluorescein nuclei. Their authors assumed that fluorescein is necessary for generation of fluorescent particles and they neglected possible fluorescence of DEHS itself. Our analysis of DEHS characteristics indicated that DEHS fluorescence could be detected apart in sufficient rate to evaluate aerosol deposition. Consequently experiments in standard setup of condensation monodisperse aerosol generator with sodium chloride nuclei instead of fluorescein were performed. Results demonstrating applicability and limitations of DEHS particles for fluorometric deposition measurements are presented and discussed.

Keywords

aerosol deposition, DEHS, lung model

RIV year

2011

Released

22.11.2011

Publisher

Technical University of Liberec

Location

Liberec, Czech Republic

ISBN

978-80-7372-784-0

Book

Experimental Fluid Mechanics 2011 Conference Proceedings Volume 1

Pages from

281

Pages to

288

Pages count

9

BibTex


@inproceedings{BUT92795,
  author="František {Lízal} and Jan {Jedelský} and Josef {Lippay} and Tereza {Venerová} and Filip {Mravec} and Miroslav {Jícha}",
  title="Aerosol Transport in a Model of Human Lungs",
  annote="Complex flow structures emerging in human lungs significantly affect deposition of inhaled particles. Therefore flow measurements alongside with deposition measurements have to be performed on the same model geometry. Amount of deposited aerosol particles in different regions of lungs could be measured by several methods. Gamma detection of radioactive tagged particles is subjected to strict regulations and is expensive; gravimetry and fluorometry are thus preferred in current studies.
Novel methodology for fluorometric measurement of aerosol transport in models of human lungs was developed. Some previously published experiments were performed using condensation of di(2-ethylhexyl) sebacate (DEHS) vapours on fluorescein nuclei. Their authors assumed that fluorescein is necessary for generation of fluorescent particles and they neglected possible fluorescence of DEHS itself. Our analysis of DEHS characteristics indicated that DEHS fluorescence could be detected apart in sufficient rate to evaluate aerosol deposition. Consequently experiments in standard setup of condensation monodisperse aerosol generator with sodium chloride nuclei instead of fluorescein were performed. Results demonstrating applicability and limitations of DEHS particles for fluorometric deposition measurements are presented and discussed.",
  address="Technical University of Liberec",
  booktitle="Experimental Fluid Mechanics 2011 Conference Proceedings Volume 1",
  chapter="92795",
  howpublished="print",
  institution="Technical University of Liberec",
  year="2011",
  month="november",
  pages="281--288",
  publisher="Technical University of Liberec",
  type="conference paper"
}