Publication detail

Experimental model of human airways for flow, particle transport and deposition study

JEDELSKÝ, J. LÍZAL, F. JÍCHA, M. KRŠEK, P. ŠTĚTINA, J. KOŠNER, J.

Original Title

Experimental model of human airways for flow, particle transport and deposition study

English Title

Experimental model of human airways for flow, particle transport and deposition study

Type

abstract

Language

en

Original Abstract

Better understanding of the transport, penetration and dispersion of particles as well as their deposition in the human lungs is needed to increase transport efficiency of therapeutic drugs. One of the approaches is an experimental investigation of flow in transparent airway model by optical methods. To enable optical measurement of aerosol transport with air as working fluid, we created realistic thin-walled transparent model of the airways. Aerosol is generated in desired size and concentration and the breathing cycle is simulated by pneumatic mechanism. Novel technique was developed for manufacturing of thin-walled lung model. As a generator of oscillating flow, a servo motor which drives piston through the cylinder is used. The servo motor is computer controlled and it allows generating any shape of motion with appropriate frequency and amplitude. Monodisperse aerosol particles of DEHS ranging from 1 to 10 um, used for deposition study and flow visualization in optical measurements are generated by condensation generator. Measurement of drop size and concentration is made by an aerosol monitor.

English abstract

Better understanding of the transport, penetration and dispersion of particles as well as their deposition in the human lungs is needed to increase transport efficiency of therapeutic drugs. One of the approaches is an experimental investigation of flow in transparent airway model by optical methods. To enable optical measurement of aerosol transport with air as working fluid, we created realistic thin-walled transparent model of the airways. Aerosol is generated in desired size and concentration and the breathing cycle is simulated by pneumatic mechanism. Novel technique was developed for manufacturing of thin-walled lung model. As a generator of oscillating flow, a servo motor which drives piston through the cylinder is used. The servo motor is computer controlled and it allows generating any shape of motion with appropriate frequency and amplitude. Monodisperse aerosol particles of DEHS ranging from 1 to 10 um, used for deposition study and flow visualization in optical measurements are generated by condensation generator. Measurement of drop size and concentration is made by an aerosol monitor.

Keywords

lung model, aerosol measurement, lung deposition, Laser Doppler anemometry

RIV year

2008

Released

25.08.2008

Publisher

Hellenic Associacion for Aerosol Research

Location

Thessaloniki, Greace

Pages from

1

Pages to

1

Pages count

1

BibTex


@misc{BUT60970,
  author="Jan {Jedelský} and František {Lízal} and Miroslav {Jícha} and Přemysl {Kršek} and Josef {Štětina} and Jan {Košner}",
  title="Experimental model of human airways for flow, particle transport and deposition study",
  annote="Better understanding of the transport, penetration and dispersion of particles as well as their deposition in the human lungs is needed to increase transport efficiency of therapeutic drugs. One of the approaches is an experimental investigation of flow in transparent airway model by optical methods. To enable optical measurement of aerosol transport with air as working fluid, we created realistic thin-walled transparent model of the airways. Aerosol is generated in desired size and concentration and the breathing cycle is simulated by pneumatic mechanism. Novel technique was developed for manufacturing of thin-walled lung model. As a generator of oscillating flow, a servo motor which drives piston through the cylinder is used. The servo motor is computer controlled and it allows generating any shape of motion with appropriate frequency and amplitude. Monodisperse aerosol particles of DEHS ranging from 1 to 10 um, used for deposition study and flow visualization in optical measurements are generated by condensation generator. Measurement of drop size and concentration is made by an aerosol monitor.",
  address="Hellenic Associacion for Aerosol Research",
  booktitle="Sborník z European aerosol conference. Thessaloniki, Greace. 2008",
  chapter="60970",
  edition="1",
  institution="Hellenic Associacion for Aerosol Research",
  year="2008",
  month="august",
  pages="1--1",
  publisher="Hellenic Associacion for Aerosol Research",
  type="abstract"
}