Publication detail

Impact Of Parapapillary Autofluorescence In Glaucoma: Clinical Aspects

LAEMMER, R. KOLÁŘ, R. JAN, J. MARDIN, C.

Original Title

Impact Of Parapapillary Autofluorescence In Glaucoma: Clinical Aspects

Czech Title

Impact Of Parapapillary Autofluorescence In Glaucoma: Clinical Aspects

English Title

Impact Of Parapapillary Autofluorescence In Glaucoma: Clinical Aspects

Type

journal article

Language

cs

Original Abstract

Parapapillary atrophy is an important clinical sign associated with progressive optic disc damage and visual field loss in patients with glaucoma. Histologic and spectroscopic results revealed an accumulation of lipofuscin as the dominant fundus fluorophore localized in the lysosomes of the retinal pigmentepithelium in the parapapillary atrophic zone. We investigated morphologic characteristics of parapapillary autofluorescence in patients with different entities and stages of glaucoma compared to healthy controls using Scanning Laser Ophthalmoscopy. Autofluorescence was measured with HRA standard software and compared to a new semiautomatic approach. Both, area and mean distance of the autofluorescence regions from the optic disc border were well associated with increasing glaucomatous damage. Changes were more pronounced for early stages. Semiautomatic segmentation improved interobserver variability.

Czech abstract

Parapapillary atrophy is an important clinical sign associated with progressive optic disc damage and visual field loss in patients with glaucoma. Histologic and spectroscopic results revealed an accumulation of lipofuscin as the dominant fundus fluorophore localized in the lysosomes of the retinal pigmentepithelium in the parapapillary atrophic zone. We investigated morphologic characteristics of parapapillary autofluorescence in patients with different entities and stages of glaucoma compared to healthy controls using Scanning Laser Ophthalmoscopy. Autofluorescence was measured with HRA standard software and compared to a new semiautomatic approach. Both, area and mean distance of the autofluorescence regions from the optic disc border were well associated with increasing glaucomatous damage. Changes were more pronounced for early stages. Semiautomatic segmentation improved interobserver variability.

English abstract

Parapapillary atrophy is an important clinical sign associated with progressive optic disc damage and visual field loss in patients with glaucoma. Histologic and spectroscopic results revealed an accumulation of lipofuscin as the dominant fundus fluorophore localized in the lysosomes of the retinal pigmentepithelium in the parapapillary atrophic zone. We investigated morphologic characteristics of parapapillary autofluorescence in patients with different entities and stages of glaucoma compared to healthy controls using Scanning Laser Ophthalmoscopy. Autofluorescence was measured with HRA standard software and compared to a new semiautomatic approach. Both, area and mean distance of the autofluorescence regions from the optic disc border were well associated with increasing glaucomatous damage. Changes were more pronounced for early stages. Semiautomatic segmentation improved interobserver variability.

Keywords

glaucoma, retinal imaging, autofluorescence

RIV year

2008

Released

27.06.2008

Pages from

1

Pages to

4

Pages count

4

BibTex


@article{BUT49681,
  author="Radim {Kolář} and Robert {Laemmer} and Jiří {Jan} and Christian Y {Mardin}",
  title="Impact Of Parapapillary Autofluorescence In Glaucoma: Clinical Aspects",
  annote="Parapapillary atrophy is an important clinical sign associated with progressive  optic disc damage and visual field loss  in patients with glaucoma. Histologic and spectroscopic results revealed an accumulation of lipofuscin as the dominant fundus fluorophore localized in the lysosomes of the retinal pigmentepithelium in the parapapillary atrophic zone. We investigated morphologic characteristics of parapapillary autofluorescence in patients with different entities and stages of glaucoma compared to healthy controls using Scanning Laser Ophthalmoscopy. Autofluorescence was measured with HRA standard software and compared to a new semiautomatic approach. Both, area and mean distance of the autofluorescence regions from the optic disc border were well associated with increasing glaucomatous damage. Changes were more pronounced for early 
stages. Semiautomatic segmentation improved interobserver variability.",
  chapter="49681",
  journal="Analysis of Biomedical Signals and Images",
  number="1",
  volume="19",
  year="2008",
  month="june",
  pages="1--4",
  type="journal article"
}