Publication detail

FE models of stress-strain states in vascular smooth muscle cell

BURŠA, J. LEBIŠ, R. JANÍČEK, P.

Original Title

FE models of stress-strain states in vascular smooth muscle cell

English Title

FE models of stress-strain states in vascular smooth muscle cell

Type

journal article - other

Language

en

Original Abstract

The paper deals with problems related to computational modelling of stress-strain states in vascular smooth muscle cells (SMCs). First, motivation for stress-strain analysis of SMCs is presented. Problems of their structure, geometry, constitutive models and initial (stress-free) state are analyzed on the basis of anatomical, histological and physiological knowledge. Various types of computational FE models of SMCs are presented; their constitutive models are identified on the basis of published mechanical tests carried out with SMCs cultured in vitro. Results of two models are presented; the former is a homogeneous model of the cell tension test with hyperelastic constitutive relations of the cell material. The latter model is more complex, it comprehends cortical and deep cytoskeleton, modelled as a tensegrity structure, and homogeneous linear elastic nucleus and remaining cytoplasm; it is used in computational modelling of indentation test. Perspectives, assumptions and limitations of computational modelling of SMCs under physiological load are discussed.

English abstract

The paper deals with problems related to computational modelling of stress-strain states in vascular smooth muscle cells (SMCs). First, motivation for stress-strain analysis of SMCs is presented. Problems of their structure, geometry, constitutive models and initial (stress-free) state are analyzed on the basis of anatomical, histological and physiological knowledge. Various types of computational FE models of SMCs are presented; their constitutive models are identified on the basis of published mechanical tests carried out with SMCs cultured in vitro. Results of two models are presented; the former is a homogeneous model of the cell tension test with hyperelastic constitutive relations of the cell material. The latter model is more complex, it comprehends cortical and deep cytoskeleton, modelled as a tensegrity structure, and homogeneous linear elastic nucleus and remaining cytoplasm; it is used in computational modelling of indentation test. Perspectives, assumptions and limitations of computational modelling of SMCs under physiological load are discussed.

Keywords

smooth muscle cell, finite element method, tensegrity, mechanical test, computational simulation

RIV year

2006

Released

10.10.2006

Publisher

IOS Press

Location

Nieuwe Hemweg 6B, 1013 BG, The Netherlands

Pages from

311

Pages to

320

Pages count

10

Documents

BibTex


@article{BUT43914,
  author="Jiří {Burša} and Radek {Lebiš} and Přemysl {Janíček}",
  title="FE models of stress-strain states in vascular smooth muscle cell",
  annote="The paper deals with problems related to computational modelling of stress-strain states in vascular smooth muscle
cells (SMCs). First, motivation for stress-strain analysis of SMCs is presented. Problems of their structure, geometry, constitutive
models and initial (stress-free) state are analyzed on the basis of anatomical, histological and physiological knowledge. Various
types of computational FE models of SMCs are presented; their constitutive models are identified on the basis of published
mechanical tests carried out with SMCs cultured in vitro. Results of two models are presented; the former is a homogeneous
model of the cell tension test with hyperelastic constitutive relations of the cell material. The latter model is more complex, it
comprehends cortical and deep cytoskeleton, modelled as a tensegrity structure, and homogeneous linear elastic nucleus and
remaining cytoplasm; it is used in computational modelling of indentation test. Perspectives, assumptions and limitations of
computational modelling of SMCs under physiological load are discussed.",
  address="IOS Press",
  chapter="43914",
  institution="IOS Press",
  journal="Technology and Health Care, Int. Journal of Health Care Engineering",
  number="4,5",
  volume="14",
  year="2006",
  month="october",
  pages="311--320",
  publisher="IOS Press",
  type="journal article - other"
}