Publication detail

I/D ACE gene polymorphism in survival of leukemia patients - hypothesis and pilot study

HÁJEK, D. TOMISKA, M. KRAHULCOVÁ, E. DRUCKMÜLLER, M. FLORIÁNOVÁ, M. IZAKOVIČOVÁ-HOLLÁ, L. VÁCHA, J.

Original Title

I/D ACE gene polymorphism in survival of leukemia patients - hypothesis and pilot study

Type

journal article - other

Language

English

Original Abstract

Angiotensin-I converting enzyme (ACE) is involved not only in intracellular volume regulation but also in proliferation control. Since both ACE gene polymorphism (I/D ACE) and ABO blood group determine ACE level in peripheral blood and probably also in bone marrow, the hypothesis to the interindividual differences in survival of leukemic patients was suggested.The data of 25 patients of both sexes with acute myelogenous (AML), acute lymphatic (ALL), chronic myelogenous (CML) and chronic lymphatic (CLL) leukemia treated by conventional were used for the study.The overall survival (SUR) was estimated as the time from the date of diagnosis to the date of death. The difference between patient's individual SUR (iSUR) and median SUR according to the type of leukemia (mSUR) was calculated. This difference (iSUR-mSUR) varied with I/D ACE genotype (p<0.02) but neither with diagnosis nor with ABO blood group. The regression model for iSUR calculation, from mSUR and I/D ACE genotype, has been suggested.

Keywords

chronic lymphatic leukemia

Authors

HÁJEK, D.; TOMISKA, M.; KRAHULCOVÁ, E.; DRUCKMÜLLER, M.; FLORIÁNOVÁ, M.; IZAKOVIČOVÁ-HOLLÁ, L.; VÁCHA, J.

Released

1. 7. 2003

Publisher

Elsevier

Location

Spojené království

ISBN

0306-9877

Periodical

Medical Hypotheses

Year of study

2003

Number

1

State

United Kingdom of Great Britain and Northern Ireland

Pages from

80

Pages to

84

Pages count

5

URL

http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=12781647&dopt=Abstract

BibTex

@article{BUT43808,
  author="Dobroslav {Hájek} and Miroslav {Tomiska} and Eva {Krahulcová} and Miloslav {Druckmüller} and Marie {Floriánová} and Ludmila {Izakovičová-Hollá} and Jan {Vácha}",
  title="I/D ACE gene polymorphism in survival of leukemia patients - hypothesis and pilot study",
  journal="Medical Hypotheses",
  year="2003",
  volume="2003",
  number="1",
  pages="5",
  issn="0306-9877",
  url="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=12781647&dopt=Abstract"
}