Publication detail

EXPERIMENTAL STUDY OF AEROSOL DEPOSITION IN A REALISTIC MODEL OF THE LUNG

LÍZAL, F. ELCNER, J. JEDELSKÝ, J. JÍCHA, M.

Original Title

EXPERIMENTAL STUDY OF AEROSOL DEPOSITION IN A REALISTIC MODEL OF THE LUNG

English Title

EXPERIMENTAL STUDY OF AEROSOL DEPOSITION IN A REALISTIC MODEL OF THE LUNG

Type

conference paper

Language

en

Original Abstract

The inhalation route for administration of medicaments is becoming more and more popular in recent years. The reason is non-invasiveness of the method and instantaneous absorption of drugs to the blood circulation. It is necessary to deliver exact amount of drug to the specific segment because of occurrence of diverse diseases in different segments of lungs. The aim of our work is to contribute to better understanding of transport and deposition of aerosolized drugs in lungs and hence to more effective treatment of respiratory diseases due to the targeted drug delivery. We provided measurements of aerosol deposition in segmented realistic model of lungs without a mouth cavity. Monodisperse particles marked with fluorescein were supplied to the model. The model was then disassembled to segments and each segment was rinsed with isopropanol, whereby fluorescent samples were created. Each sample was analysed by fluorometer and an amount of aerosol deposited in the segment was calculated. Experiences obtained by this study were used for creation of a new model with the mouth cavity. This model will be used for future studies with porous and fiber aerosols.

English abstract

The inhalation route for administration of medicaments is becoming more and more popular in recent years. The reason is non-invasiveness of the method and instantaneous absorption of drugs to the blood circulation. It is necessary to deliver exact amount of drug to the specific segment because of occurrence of diverse diseases in different segments of lungs. The aim of our work is to contribute to better understanding of transport and deposition of aerosolized drugs in lungs and hence to more effective treatment of respiratory diseases due to the targeted drug delivery. We provided measurements of aerosol deposition in segmented realistic model of lungs without a mouth cavity. Monodisperse particles marked with fluorescein were supplied to the model. The model was then disassembled to segments and each segment was rinsed with isopropanol, whereby fluorescent samples were created. Each sample was analysed by fluorometer and an amount of aerosol deposited in the segment was calculated. Experiences obtained by this study were used for creation of a new model with the mouth cavity. This model will be used for future studies with porous and fiber aerosols.

Keywords

realistic lung model, lung model, lung deposition, aerosol deposition, aerosol

RIV year

2010

Released

23.06.2010

Publisher

VŠB - TU Ostrava

Location

Rožnov pod Radhoštěm

ISBN

978-80-248-2244-0

Book

XXIX. mezinárodní konference Setkání kateder mechaniky tekutin a termomechaniky

Pages from

175

Pages to

178

Pages count

4

BibTex


@inproceedings{BUT33324,
  author="František {Lízal} and Jakub {Elcner} and Jan {Jedelský} and Miroslav {Jícha}",
  title="EXPERIMENTAL STUDY OF AEROSOL DEPOSITION IN A REALISTIC MODEL OF THE LUNG",
  annote="The inhalation route for administration of medicaments is becoming more and more popular in recent years. The reason is non-invasiveness of the method and instantaneous absorption of drugs to the blood circulation. It is necessary to deliver exact amount of drug to the specific segment because of occurrence of diverse diseases in different segments of lungs. The aim of our work is to contribute to better understanding of transport and deposition of aerosolized drugs in lungs and hence to more effective treatment of respiratory diseases due to the targeted drug delivery. We provided measurements of aerosol deposition in segmented realistic model of lungs without a mouth cavity. Monodisperse particles marked with fluorescein were supplied to the model. The model was then disassembled to segments and each segment was rinsed with isopropanol, whereby fluorescent samples were created. Each sample was analysed by fluorometer and an amount of aerosol deposited in the segment was calculated. Experiences obtained by this study were used for creation of a new model with the mouth cavity. This model will be used for future studies with porous and fiber aerosols.",
  address="VŠB - TU Ostrava",
  booktitle="XXIX. mezinárodní konference Setkání kateder mechaniky tekutin a termomechaniky",
  chapter="33324",
  howpublished="print",
  institution="VŠB - TU Ostrava",
  year="2010",
  month="june",
  pages="175--178",
  publisher="VŠB - TU Ostrava",
  type="conference paper"
}