Publication detail

A novel ruthenium based coordination compound against pathogenic bacteria

SUR, V. MAZUMDAR, A. KOPEL, P. MUKHERJEE, S. VÍTEK, P. MICHÁLKOVÁ, H. VACULOVIČOVÁ, M. MOULICK, A.

Original Title

A novel ruthenium based coordination compound against pathogenic bacteria

Type

journal article in Web of Science

Language

English

Original Abstract

The current epidemic of antibiotic-resistant infections urges to develop alternatives to less-effective antibiotics. To assess anti-bacterial potential, a novel coordinate compound (RU-S4) was synthesized using ruthenium-Schiff base-benzimidazole ligand, where ruthenium chloride was used as the central atom. RU-S4 was characterized by scanning electron microscope (SEM), energy-dispersive X-ray spectroscopy (EDS), and Raman spectroscopy. Antibacterial effect of RU-S4 was studied against Staphylococcus aureus (NCTC 8511), vancomycin-resistant Staphylococcus aureus (VRSA) (CCM 1767), methicillin-resistant Staphylococcus aureus (MRSA) (ST239: SCCmecIIIA), and hospital isolate Staphylococcus epidermidis. The antibacterial activity of RU-S4 was checked by growth curve analysis and the outcome was supported by optical microscopy imaging and fluorescence LIVE/DEAD cell imaging. In vivo (balb/c mice) infection model prepared with VRSA (CCM 1767) and treated with RU-S4. In our experimental conditions, all infected mice were cured. The interaction of coordination compound with bacterial cells were further confirmed by cryo-scanning electron microscope (Cryo-SEM). RU-S4 was completely non-toxic against mammalian cells and in mice and subsequently treated with synthesized RU-S4.

Keywords

coordination compound; antimicrobial compound; ruthenium; benzimidazole; SEM; EDS

Authors

SUR, V.; MAZUMDAR, A.; KOPEL, P.; MUKHERJEE, S.; VÍTEK, P.; MICHÁLKOVÁ, H.; VACULOVIČOVÁ, M.; MOULICK, A.

Released

10. 4. 2020

Publisher

MDPI

ISBN

1422-0067

Periodical

International Journal of Molecular Sciences

Year of study

21

Number

7

State

Swiss Confederation

Pages from

1

Pages to

18

Pages count

18

URL

https://www.mdpi.com/1422-0067/21/7/2656

Full text in the Digital Library

http://hdl.handle.net/11012/189392

BibTex

@article{BUT164290,
  author="Vishma Pratap {Sur} and Aninda {Mazumdar} and Pavel {Kopel} and S. {Mukherjee} and Petr {Vítek} and Hana {Michálková} and Markéta {Vaculovičová} and Amitava {Moulick}",
  title="A novel ruthenium based coordination compound against pathogenic bacteria",
  journal="International Journal of Molecular Sciences",
  year="2020",
  volume="21",
  number="7",
  pages="1--18",
  doi="10.3390/ijms21072656",
  issn="1422-0067",
  url="https://www.mdpi.com/1422-0067/21/7/2656"
}