Publication detail

Gold nanoparticles modified screen printed carbon electrode as a tool for detection of TP53

KOUDELKOVÁ, Z. SEDLÁČKOVÁ, E. RICHTERA, L. ŠVEC, P. ADAM, V.

Original Title

Gold nanoparticles modified screen printed carbon electrode as a tool for detection of TP53

Type

conference paper

Language

English

Original Abstract

Cancer is one of the most common causes of death in developing countries and in the developed world. The function of the p53 protein plays an important role in the development of cancer. The protein p53 regulates the expression of genes that are responsible for the control of cell growth, apoptosis or for repair of damaged DNA. It t is encoded by the tumor suppressor gene TP53. If this gene mutates, its product will be damaged. It was found that mutations in the TP53 gene is present in more than 50% of cancer cases. Electrochemical biosensors have proved to be a suitable method for the detection of TP53 and also its mutations. Electrochemical deposition of gold nanoparticles on the surface of working electrode increases the active surface area of the sensor, this leads to a more sensitive detection of the TP53 gene and its mutations. By developing an electrochemical biosensor based on gold nanoparticles modified screen printed electrodes, an efficient platform for detecting the TP53 gene in biological samples is obtained.

Keywords

Screen printed electrode; gold nanoparticles; gene TP53; protein p53; electrochemistry

Authors

KOUDELKOVÁ, Z.; SEDLÁČKOVÁ, E.; RICHTERA, L.; ŠVEC, P.; ADAM, V.

Released

10. 6. 2020

Publisher

Tanger

ISBN

978-80-87294-95-6

Book

NANOCON 2019 CONFERENCE PROCEEDINGS

Edition

1.

Pages from

402

Pages to

405

Pages count

4

URL

https://doi.org/10.37904/nanocon.2019.8611

Full text in the Digital Library

http://hdl.handle.net/11012/196674

BibTex

@inproceedings{BUT164268,
  author="Zuzana {Koudelková} and Eliška {Dostálová} and Lukáš {Richtera} and Pavel {Švec} and Vojtěch {Adam}",
  title="Gold nanoparticles modified screen printed carbon electrode as a tool for detection of TP53",
  booktitle="NANOCON 2019 CONFERENCE PROCEEDINGS",
  year="2020",
  series="1.",
  pages="402--405",
  publisher="Tanger",
  doi="10.37904/nanocon.2019.8611",
  isbn="978-80-87294-95-6",
  url="https://doi.org/10.37904/nanocon.2019.8611"
}