Publication detail

Luminescent Diamond Nanoparticles: Physical, Chemical and Biological Aspects of the Phenomenon (Retracted Article)

KRATOCHVÍLOVÁ, I. ASHCHEULOV, P. KOVALENKO, A. ZÁLIŠ, S. LEDVINA, M. MÍČOVÁ, J.

Original Title

Luminescent Diamond Nanoparticles: Physical, Chemical and Biological Aspects of the Phenomenon (Retracted Article)

English Title

Luminescent Diamond Nanoparticles: Physical, Chemical and Biological Aspects of the Phenomenon (Retracted Article)

Type

journal article in Web of Science

Language

en

Original Abstract

Biosensors based on nanodiamonds are able to penetrate through the cell membrane in a targeted manner and probe changes in real-time in the inner cellular space. In this work we performed exclusive theoretical and experimental study of nanodiamond particles adjusted for application in optically-traceable intracellular nanodiamond sensors. Theoretical and experimental study of specific optical properties of high-pressure high-temperature nanodiamonds containing NV- and NV0 centres were performed. The results are supported by theoretical modeling. The final result of this study was detection of luminescence ND in living cells and in vivo application od luminiscence NDs in chicken embryo, showing the detectability of luminescence ND using a standard confocal microscope. On the level of in cells selectivity numerous clusters of ND particles were present within the cytoplasm and at the same time no particles were absent in the nucleus-ND particles can be used as imaging or delivery system for specific cell parts targeting. From our study we can say that biosensors based on nanodiamonds (NDs) are able to penetrate through the cell membrane in a targeted manner and probe changes in the inner cellular space.

English abstract

Biosensors based on nanodiamonds are able to penetrate through the cell membrane in a targeted manner and probe changes in real-time in the inner cellular space. In this work we performed exclusive theoretical and experimental study of nanodiamond particles adjusted for application in optically-traceable intracellular nanodiamond sensors. Theoretical and experimental study of specific optical properties of high-pressure high-temperature nanodiamonds containing NV- and NV0 centres were performed. The results are supported by theoretical modeling. The final result of this study was detection of luminescence ND in living cells and in vivo application od luminiscence NDs in chicken embryo, showing the detectability of luminescence ND using a standard confocal microscope. On the level of in cells selectivity numerous clusters of ND particles were present within the cytoplasm and at the same time no particles were absent in the nucleus-ND particles can be used as imaging or delivery system for specific cell parts targeting. From our study we can say that biosensors based on nanodiamonds (NDs) are able to penetrate through the cell membrane in a targeted manner and probe changes in the inner cellular space.

Keywords

Nanodiamonds Luminiscence; NV Centres; In-Cells Imaging; In-Vivo Imaging

Released

01.09.2015

Publisher

AMER SCIENTIFIC PUBLISHERS

Location

VALENCIA

ISBN

1533-4899

Periodical

JOURNAL OF NANOSCIENCE AND NANOTECHNOLOGY

Year of study

15

Number

2

State

US

Pages from

1000

Pages to

1005

Pages count

6

URL

Documents

BibTex


@article{BUT163321,
  author="Irena {Kratochvílová} and Petr {Ashcheulov} and Alexander {Kovalenko} and Stanislav {Záliš} and Miroslav {Ledvina} and Julia {Míčová}",
  title="Luminescent Diamond Nanoparticles: Physical, Chemical and Biological Aspects of the Phenomenon (Retracted Article)",
  annote="Biosensors based on nanodiamonds are able to penetrate through the cell membrane in a targeted manner and probe changes in real-time in the inner cellular space. In this work we performed exclusive theoretical and experimental study of nanodiamond particles adjusted for application in optically-traceable intracellular nanodiamond sensors. Theoretical and experimental study of specific optical properties of high-pressure high-temperature nanodiamonds containing NV- and NV0 centres were performed. The results are supported by theoretical modeling. The final result of this study was detection of luminescence ND in living cells and in vivo application od luminiscence NDs in chicken embryo, showing the detectability of luminescence ND using a standard confocal microscope. On the level of in cells selectivity numerous clusters of ND particles were present within the cytoplasm and at the same time no particles were absent in the nucleus-ND particles can be used as imaging or delivery system for specific cell parts targeting. From our study we can say that biosensors based on nanodiamonds (NDs) are able to penetrate through the cell membrane in a targeted manner and probe changes in the inner cellular space.",
  address="AMER SCIENTIFIC PUBLISHERS",
  chapter="163321",
  doi="10.1166/jnn.2015.9740",
  howpublished="online",
  institution="AMER SCIENTIFIC PUBLISHERS",
  number="2",
  volume="15",
  year="2015",
  month="september",
  pages="1000--1005",
  publisher="AMER SCIENTIFIC PUBLISHERS",
  type="journal article in Web of Science"
}