Publication detail

Measurement of orientation of fibres in a simplified replica of human trachea under steady conditions

LÍZAL, F. CABALKA, M. MALÝ, M. FARKAS, Á. BĚLKA, M. ŠTARHA, P. JEDELSKÝ, J. JÍCHA, M.

Original Title

Measurement of orientation of fibres in a simplified replica of human trachea under steady conditions

English Title

Measurement of orientation of fibres in a simplified replica of human trachea under steady conditions

Type

conference proceedings

Language

en

Original Abstract

Although inhalable fibres are mostly regarded as dangerous and harmful because they are mostly associated with asbestos, several authors have recommended the application of tubular or fibrous particles for drug delivery. Chan and Gonda (1989) were among the first who ventured to enter the unexplored realm of pharmaceutically usable fibres. They prepared fibres from cromoglycic acid which has low solubility in water and therefore should not experience significant hygroscopic growth in the airways. Johnson et al. (2000) suggested packing tubular shell particles with an Active Pharmaceutical Ingredient (API) to maximise the per particle dose while targeting distal regions of lungs. Martin and Finlay (2008) have demonstrated the applicability of magnetic field targeting of magnetite-loaded fibres for efficient delivery to specified locations in lungs and encouraged other researchers to develop formulations with fibrous aerosol incorporating chemotherapeutic agents for the treatment of lung cancer.

English abstract

Although inhalable fibres are mostly regarded as dangerous and harmful because they are mostly associated with asbestos, several authors have recommended the application of tubular or fibrous particles for drug delivery. Chan and Gonda (1989) were among the first who ventured to enter the unexplored realm of pharmaceutically usable fibres. They prepared fibres from cromoglycic acid which has low solubility in water and therefore should not experience significant hygroscopic growth in the airways. Johnson et al. (2000) suggested packing tubular shell particles with an Active Pharmaceutical Ingredient (API) to maximise the per particle dose while targeting distal regions of lungs. Martin and Finlay (2008) have demonstrated the applicability of magnetic field targeting of magnetite-loaded fibres for efficient delivery to specified locations in lungs and encouraged other researchers to develop formulations with fibrous aerosol incorporating chemotherapeutic agents for the treatment of lung cancer.

Keywords

fibre, fiber, human trachea, human airways, human lungs, measurement

Released

30.10.2019

Publisher

Czech Aerosol Society

Location

Velké Bílovice

ISBN

978-80-270-6416-8

Book

PROCEEDINGS OF 20TH ANNUAL CONFERENCE OF THE CZECH AEROSOL SOCIETY

Pages count

2

URL

Documents

BibTex


@proceedings{BUT161044,
  author="František {Lízal} and Matouš {Cabalka} and Milan {Malý} and Árpád {Farkas} and Miloslav {Bělka} and Pavel {Štarha} and Jan {Jedelský} and Miroslav {Jícha}",
  title="Measurement of orientation of fibres in a simplified replica of human trachea under steady conditions",
  annote="Although inhalable fibres are mostly regarded as dangerous and harmful because they are mostly associated with asbestos, several authors have recommended the application of tubular or fibrous particles for drug delivery. Chan and Gonda (1989) were among the first who ventured to enter the unexplored realm of pharmaceutically usable fibres. They prepared fibres from cromoglycic acid which has low solubility in water and therefore should not experience significant hygroscopic growth in the airways. Johnson et al. (2000) suggested packing tubular shell particles with an Active Pharmaceutical Ingredient (API) to maximise the per particle dose while targeting distal regions of lungs. Martin and Finlay (2008) have demonstrated the applicability of magnetic field targeting of magnetite-loaded fibres for efficient delivery to specified locations in lungs and encouraged other researchers to develop formulations with fibrous aerosol incorporating chemotherapeutic agents for the treatment of lung cancer.",
  address="Czech Aerosol Society",
  booktitle="PROCEEDINGS OF 20TH ANNUAL CONFERENCE OF THE CZECH AEROSOL SOCIETY",
  chapter="161044",
  howpublished="online",
  institution="Czech Aerosol Society",
  year="2019",
  month="october",
  publisher="Czech Aerosol Society",
  type="conference proceedings"
}