Publication detail

Oriented Clonal Cell Dynamics Enables Accurate Growth and Shaping of Mammalian Facial Cartilage

KAUCKÁ, M. TESAŘOVÁ, M. ZIKMUND, T. KAISER, J. ADAMEYKO, I.

Original Title

Oriented Clonal Cell Dynamics Enables Accurate Growth and Shaping of Mammalian Facial Cartilage

Type

presentation, poster

Language

English

Original Abstract

Control of shape and size during growth of the mammalian face is highly enigmatic. Complexly shaped cartilage structures in developing face provide a great model system to tackle this question. We investigated major principles of facial cartilage induction and scaling up. We found that basic 3D-blueprint of facial cartilages is induced as early mesenchymal condensations by combinatorial signals derived from epithelia and nervous system. We also revealed that the final shape and size of every solid cartilage structure in the embryonic head are achieved through two processes going in parallel: incremental addition of adjacently-induced chondrogenic condensations combined with scaling up of the pre-laid cartilage. The scaling is accomplished through a previously unknown mechanism of growth based on introducing oriented clonal units into existing cartilage from the perichondral cell layer. We took advantage of various molecular tools to demonstrate how specific clonal dynamics in cartilage enables uncoupling lateral expansion from thickness control as well as geometrical fine-tuning.

Keywords

Conference poster

Authors

KAUCKÁ, M.; TESAŘOVÁ, M.; ZIKMUND, T.; KAISER, J.; ADAMEYKO, I.

Released

3. 6. 2019

Publisher

WILEY

ISBN

0362-2525

Periodical

JOURNAL OF MORPHOLOGY

Year of study

280

State

United States of America

Pages from

200

Pages to

201

Pages count

244

URL

https://onlinelibrary.wiley.com/doi/abs/10.1002/jmor.21003

BibTex

@misc{BUT157896,
  author="Markéta {Kaucká} and Markéta {Kaiser} and Tomáš {Zikmund} and Jozef {Kaiser} and Igor {Adameyko}",
  title="Oriented Clonal Cell Dynamics Enables Accurate Growth and Shaping of Mammalian Facial Cartilage",
  year="2019",
  journal="JOURNAL OF MORPHOLOGY",
  volume="280",
  pages="200--201",
  publisher="WILEY",
  issn="0362-2525",
  url="https://onlinelibrary.wiley.com/doi/abs/10.1002/jmor.21003",
  note="presentation, poster"
}