Publication detail

Effect of halloysite nanotube structure on physical, chemical, structural and biological properties of elastic polycaprolactone/gelatin nanofibers for wound healing applications

PAVLIŇÁKOVÁ, V. FOHLEROVÁ, Z. PAVLIŇÁK, D. KHUNOVÁ, V. VOJTOVÁ, L.

Original Title

Effect of halloysite nanotube structure on physical, chemical, structural and biological properties of elastic polycaprolactone/gelatin nanofibers for wound healing applications

English Title

Effect of halloysite nanotube structure on physical, chemical, structural and biological properties of elastic polycaprolactone/gelatin nanofibers for wound healing applications

Type

journal article in Web of Science

Language

en

Original Abstract

Nanofibrous elastic material based on the blend of hydrophobic poly(epsilon-caprolactone) (PCL) and hydrophilic gelatin (Gel) reinforced with halloysite nanotubes (HNTs) was prepared by electrospinning process by respecting principles of "green chemistry" required for tissue engineering and drug delivery carriers. Three different kinds of HNTs with similar aspect ratio, but different length and inner diameter were examined to explain the effect of HNT concentration and geometry on a structure, morphology, chemical composition, mechanical properties and biocompatibility of nanostructured materials. Reinforcing effect of each type of HNTs has been confirmed up to 6 wt%. However, the highest improvement of mechanical properties was exhibited by addition just 0.5 wt% of HNTs. All HNT modified nanofibers have been confirmed as non-cytotoxic based on the interaction with mouse fibroblasts NIH-3T3 cells and therefore suitable for biomedical applications, e.g. as wound healing coverings with controlled drug delivery.

English abstract

Nanofibrous elastic material based on the blend of hydrophobic poly(epsilon-caprolactone) (PCL) and hydrophilic gelatin (Gel) reinforced with halloysite nanotubes (HNTs) was prepared by electrospinning process by respecting principles of "green chemistry" required for tissue engineering and drug delivery carriers. Three different kinds of HNTs with similar aspect ratio, but different length and inner diameter were examined to explain the effect of HNT concentration and geometry on a structure, morphology, chemical composition, mechanical properties and biocompatibility of nanostructured materials. Reinforcing effect of each type of HNTs has been confirmed up to 6 wt%. However, the highest improvement of mechanical properties was exhibited by addition just 0.5 wt% of HNTs. All HNT modified nanofibers have been confirmed as non-cytotoxic based on the interaction with mouse fibroblasts NIH-3T3 cells and therefore suitable for biomedical applications, e.g. as wound healing coverings with controlled drug delivery.

Keywords

Electrospinning; Halloysite nanotubes; Nanofibers; Biocompatibility; Polymer nanocomposit

Released

01.10.2018

Pages from

94

Pages to

102

Pages count

9

URL

BibTex


@article{BUT148625,
  author="Veronika {Pavliňáková} and Zdenka {Fohlerová} and David {Pavliňák} and Viera {Khunová} and Lucy {Vojtová}",
  title="Effect of halloysite nanotube structure on physical, chemical, structural and biological properties of elastic polycaprolactone/gelatin nanofibers for wound healing applications",
  annote="Nanofibrous elastic material based on the blend of hydrophobic poly(epsilon-caprolactone) (PCL) and hydrophilic gelatin (Gel) reinforced with halloysite nanotubes (HNTs) was prepared by electrospinning process by respecting principles of "green chemistry" required for tissue engineering and drug delivery carriers. Three different kinds of HNTs with similar aspect ratio, but different length and inner diameter were examined to explain the effect of HNT concentration and geometry on a structure, morphology, chemical composition, mechanical properties and biocompatibility of nanostructured materials. Reinforcing effect of each type of HNTs has been confirmed up to 6 wt%. However, the highest improvement of mechanical properties was exhibited by addition just 0.5 wt% of HNTs. All HNT modified nanofibers have been confirmed as non-cytotoxic based on the interaction with mouse fibroblasts NIH-3T3 cells and therefore suitable for biomedical applications, e.g. as wound healing coverings with controlled drug delivery.",
  chapter="148625",
  doi="10.1016/j.msec.2018.05.033",
  howpublished="print",
  number="1",
  volume="91",
  year="2018",
  month="october",
  pages="94--102",
  type="journal article in Web of Science"
}