Publication detail

ANALYSIS OF DOXORUBICIN ENCAPSULATION IN APOFERRITIN CAGE BY CAPILLARY ELECTROPHORESIS WITH LASER-INDUCED FLUORESCENCE DETECTION

STANISAVLJEVIC, M. VACULOVIČOVÁ, M. KOPEL, P. ADAM, V. ECKSCHLAGER, T. KIZEK, R.

Original Title

ANALYSIS OF DOXORUBICIN ENCAPSULATION IN APOFERRITIN CAGE BY CAPILLARY ELECTROPHORESIS WITH LASER-INDUCED FLUORESCENCE DETECTION

Type

conference paper

Language

English

Original Abstract

Doxorubicin is an effective cytostatic drug used for treatment of some leukemias and Hodgkin's lymphoma, as well as cancers of the bladder, breast, stomach, lung, ovaries, thyroid, soft tissue sarcoma and/or multiple myeloma. Even though this drug is effective for cancer treatment its toxicity, mainly cardiotoxicity, is limiting the use. For this reason, encapsulation of the drug into the biocarriers, lowering the toxicity, is widely investigated. One of such carriers may be a protein called apoferritin, which is due to the cavity in its structure, able to incept the molecule of interest. Subsequent decrease of pH leads to the opening of the structure and release of the content. The aim of this study is to investigate the behavior of the encapsulated doxorubicin using capillary electrophoresis with laser-induced fluorescence detection (CE-LIF).

Keywords

doxorubicin; apoferritin; capillary electrophoresis; cancer; cytostatic drug

Authors

STANISAVLJEVIC, M.; VACULOVIČOVÁ, M.; KOPEL, P.; ADAM, V.; ECKSCHLAGER, T.; KIZEK, R.

Released

2. 11. 2012

ISBN

978-80-904959-1-3

Book

CECE 2012

Pages from

209

Pages to

212

Pages count

4

BibTex

@inproceedings{BUT145848,
  author="Maja {Stanisavljevic} and Markéta {Vaculovičová} and Pavel {Kopel} and Vojtěch {Adam} and Tomáš {Eckschlager} and René {Kizek}",
  title="ANALYSIS OF DOXORUBICIN ENCAPSULATION IN APOFERRITIN CAGE BY CAPILLARY ELECTROPHORESIS WITH LASER-INDUCED FLUORESCENCE DETECTION",
  booktitle="CECE 2012",
  year="2012",
  pages="209--212",
  isbn="978-80-904959-1-3"
}