Publication detail

USE OF THE SILVER PHOSPHATE NANOPARTICLES (SPNPs) FOR THEIR ANTIMICROBIAL EFFECT ON BACTERIAL STRAINS

CHUDOBOVA, D. ČÍHALOVÁ, K. RUTTKAY-NEDECKÝ, B. KOPEL, P. ŽŮREK, M. BASTL, K. ADAM, V. KIZEK, R.

Original Title

USE OF THE SILVER PHOSPHATE NANOPARTICLES (SPNPs) FOR THEIR ANTIMICROBIAL EFFECT ON BACTERIAL STRAINS

Type

conference paper

Language

English

Original Abstract

Bacterial infections caused by Gram- or Gram(+) bacteria can be a serious complication in the treatment of many diseases. These strains are a common producer of nosocomial infections, which can be acquired in hospitals. The aim of many studies is to prevent these infections using various technical and technological procedures. For comparison of the antimicrobial effect of silver phosphate nanoparticles (SPNPs) in complexes with hyaluronic acid or chitosan on S. aureus and E. coli (8.0 * 10(7) CFU/1 ml), minimal inhibition concentration (MIC) was determined. SPNPs with typical spherical structure (200-300 nm) and compact structure were prepared. MIC of S. aureus with complex of hyaluronic acid with SPNPs resulted from the concentration of 25 mu M SPNPs and the total inhibition concentration (TIC) was 225 mu M SPNPs. MIC of S. aureus with complex of chitosan with SPNPs was 10 mu M SPNPs, and TIC was 25 mu M SPNPs. In the case of E. coli bacterial culture with complex of hyaluronic acid with SPNPs was MIC determined at 10 mu M SPNPs, and TIC was 150 mu M SPNPs. Applied complex of chitosan with SPNPs has MIC 10 mu M, which was the same as TIC. The best result was achieved at E. coli bacterial strain after the application of the complex of chitosan with SPNPs. Due to the increasing severity of the problem of resistance to commonly used antibiotic drugs, the study of the substances with antimicrobial effects, especially on the basis nanotechnologies, should be a priority in the future.

Keywords

Silver phosphate nanoparticles; Hyaluronic acid; Chitosan; Antimicrobial effect

Authors

CHUDOBOVA, D.; ČÍHALOVÁ, K.; RUTTKAY-NEDECKÝ, B.; KOPEL, P.; ŽŮREK, M.; BASTL, K.; ADAM, V.; KIZEK, R.

Released

1. 12. 2014

ISBN

978-80-87294-47-5

Book

NANOCON 2013

Pages from

514

Pages to

520

Pages count

7

BibTex

@inproceedings{BUT142343,
  author="Dagmar {chudobova} and Kristýna {Číhalová} and Branislav {Ruttkay-Nedecký} and Pavel {Kopel} and Michal {Žůrek} and Karel {Bastl} and Vojtěch {Adam} and René {Kizek}",
  title="USE OF THE SILVER PHOSPHATE NANOPARTICLES (SPNPs) FOR THEIR ANTIMICROBIAL EFFECT ON BACTERIAL STRAINS",
  booktitle="NANOCON 2013",
  year="2014",
  pages="514--520",
  isbn="978-80-87294-47-5"
}