Publication detail

Peptide modified carbon nanotubes for drug delivery

MILOSAVLJEVIĆ, V. KREJČOVÁ, L. GURÁŇ, R. SKALIČKOVÁ, S. BUCHTELOVÁ, H. MOULICK, A. KOPEL, P. ADAM, V.

Original Title

Peptide modified carbon nanotubes for drug delivery

Type

conference paper

Language

English

Original Abstract

Multi-walled-carbon nanotubes (MWCNTs) are widely explored as carriers for drug delivery, due to their facile transport through cellular membranes, and are reportedly found to be effective against cancer. In the present study, we have designed a MWCNTs nanocarrier for doxorubicin delivery to prostate cancer tissue. The cell penetrating peptide (SMSIALR) modified MWCNTs provide better penetration of nanocarrier into cancer cells. Using fluorescence measurement, the doxorubicin (DOXO) binding efficiency was estimated to 100%. MALDI analysis confirms the presence of doxorubicin and peptide on the MWCNTsstructure. The stability behavior of the colloid suspension indicates the positive charge of carbon nanocarrier and due to this fact, the cancer cells membranes carry negative charge, the MWCNTs is established as suitable drug delivery system for doxorubicin.

Keywords

Multiwall carbon nanotubes; Cell penetrating peptides; Doxorubicin; Drug delivery

Authors

MILOSAVLJEVIĆ, V.; KREJČOVÁ, L.; GURÁŇ, R.; SKALIČKOVÁ, S.; BUCHTELOVÁ, H.; MOULICK, A.; KOPEL, P.; ADAM, V.

Released

9. 11. 2016

Publisher

Mendel University in Brno

Location

Brno, Czech Republic

ISBN

978-80-7509-443-8

Book

MendelNet2016

Pages from

999

Pages to

1004

Pages count

6

BibTex

@inproceedings{BUT138110,
  author="Vedran {Milosavljević} and Ludmila {Krejčová} and Roman {Guráň} and Sylvie {Skaličková} and Hana {Michálková} and Amitava {Moulick} and Pavel {Kopel} and Vojtěch {Adam}",
  title="Peptide modified carbon nanotubes for drug delivery",
  booktitle="MendelNet2016",
  year="2016",
  pages="999--1004",
  publisher="Mendel University in Brno",
  address="Brno, Czech Republic",
  isbn="978-80-7509-443-8"
}