Publication detail

Trk receptors and neurotrophins cross-interactions: New perspective to manipulating therapeutic side-effects

HADDAD, Y. ADAM, V. HEGER, Z.

Original Title

Trk receptors and neurotrophins cross-interactions: New perspective to manipulating therapeutic side-effects

Type

journal article in Web of Science

Language

English

Original Abstract

Some therapeutic side-effects result from simultaneous activation of homolog receptors by the same ligand. Tropomyosin receptor kinases (TrkA, TrkB and TrkC) play a major role in the development and biology of neurons through neurotrophin signaling. The wide range of cross-interactions between Trk receptors and neurotrophins vary in selectivity, affinity and function. In this study, we discuss new perspectives to the manipulation of side-effects via a better understanding of the cross-interactions at the molecular level, derived by computational methods. Available crystal structures of Trk receptors and neurotrophins are a valuable resource for exploitation via molecular mechanics (MM) and dynamics (MD). The study of the energetics and dynamics of neurotrophins or neurotrophic peptides interacting with Trk receptors will provide insight to structural regions that may be candidates for drug targeting and signaling pathway selection.

Keywords

drug side-effect; molecular dynamics; molecular mechanics; neurotrophic tyrosine kinase receptor; neurotrophin; tropomyosin receptor kinase

Authors

HADDAD, Y.; ADAM, V.; HEGER, Z.

Released

3. 5. 2017

Publisher

Frontiers

ISBN

1662-5099

Periodical

Frontiers in Molecular Neuroscience

Year of study

10

Number

130

State

Swiss Confederation

Pages from

1

Pages to

7

Pages count

7

URL

http://journal.frontiersin.org/article/10.3389/fnmol.2017.00130/full

Full text in the Digital Library

http://hdl.handle.net/11012/69383

BibTex

@article{BUT137551,
  author="Yazan Abdulmajeed Eyadh {Haddad} and Vojtěch {Adam} and Zbyněk {Heger}",
  title="Trk receptors and neurotrophins cross-interactions: New perspective to manipulating therapeutic side-effects",
  journal="Frontiers in Molecular Neuroscience",
  year="2017",
  volume="10",
  number="130",
  pages="1--7",
  doi="10.3389/fnmol.2017.00130",
  issn="1662-5099",
  url="http://journal.frontiersin.org/article/10.3389/fnmol.2017.00130/full"
}