Publication detail

Physicochemical investigation of stability of apoferritin with encapsulated doxorubicin

DOSTÁLOVÁ, S. VAŠÍČKOVÁ, K. HYNEK, D. KŘÍŽKOVÁ, S. RICHTERA, L. HEGER, Z. VACULOVIČOVÁ, M. STIBOROVÁ, M. ADAM, V.

Original Title

Physicochemical investigation of stability of apoferritin with encapsulated doxorubicin

Type

conference paper

Language

English

Original Abstract

The many negative side effects of drugs used for treatment of highly diverse diseases, such as cancer, lead in recent years to the development of ways how to target the drug selectively to the diseased tissue while avoiding the healthy cells. Nanocarriers, made from various materials, can serve as a suitable platform for this targeted drug delivery. Herein, we evaluate the long-term stability of nanocarrier based on ubiquitous protein apoferritin with encapsulated doxorubicin. Various properties of the nanocarrier were observed over the course of 12 weeks while stored at various temperatures, such as premature drug release, optical properties of the encapsulated drug, nanocarrier size and surface zeta potential. The nanocarrier showed very good stability for up to 12 weeks with the best results observed with nanocarrier prepared in water and stored at dark at 4 °C.

Keywords

absorbance; fluorescence; nanomedicine; surface zeta potential

Authors

DOSTÁLOVÁ, S.; VAŠÍČKOVÁ, K.; HYNEK, D.; KŘÍŽKOVÁ, S.; RICHTERA, L.; HEGER, Z.; VACULOVIČOVÁ, M.; STIBOROVÁ, M.; ADAM, V.

Released

12. 12. 2016

Location

Brno

ISBN

978-80-7509-443-8

Book

MendelNet2016

Pages from

966

Pages to

971

Pages count

6

BibTex

@inproceedings{BUT133384,
  author="DOSTÁLOVÁ, S. and VAŠÍČKOVÁ, K. and HYNEK, D. and KŘÍŽKOVÁ, S. and RICHTERA, L. and HEGER, Z. and VACULOVIČOVÁ, M. and STIBOROVÁ, M. and ADAM, V.",
  title="Physicochemical investigation of stability of apoferritin with encapsulated doxorubicin",
  booktitle="MendelNet2016",
  year="2016",
  pages="966--971",
  address="Brno",
  isbn="978-80-7509-443-8"
}