Publication detail

Can we improve the therapy of Clostridium difficile infection in elderly patients?

Bielakova, K Fernandova, E Matejovska-Kubesova, H Weber, P Prudius, D Bednar, J

Original Title

Can we improve the therapy of Clostridium difficile infection in elderly patients?

Type

journal article in Web of Science

Language

English

Original Abstract

Clostridium difficile infection (CDI) is becoming a serious problem predominantly in geriatric patients, who are a significant risk group. The goal of this study was to evaluate the risk factors for mortality in CDI patients and to construct a binary logistic regression model that describes the probability of mortality in geriatric patients suffering from CDI. In this retrospective study, we evaluated a group of 235 patients over 65 years of age with confirmed diagnoses of CDI, hospitalized at the Department of Internal Medicine, Geriatrics and General Practice, Brno, from January 2008 to December 2013. The examined group comprised 148 women (63 %) and 87 men (37 %). For the diagnosis of CDI, confirmation of A and B toxins in the patients' stool or an autopsy confirmation was crucial. The impact of antibiotic therapy on the increased incidence of CDI was clearly confirmed in our study group when examining patients' histories. Other risk factors included cerebrovascular disease, dementia, the presence of pressure ulcers, and immobility. Our new model consisted of a combination of the following parameters: the number of antibiotics used (from patients' history), nutritional status (Mini Nutritional Assessment short-form test), presence of pressure ulcers, and occurrence of fever.

Keywords

Clostridium difficile; Geriatric patient; Antibiotic therapy; Pseudomebranous colitis; Binary logistic regression model

Authors

Bielakova, K; Fernandova, E; Matejovska-Kubesova, H; Weber, P; Prudius, D; Bednar, J

Released

1. 8. 2016

Publisher

SPRINGER WIEN

Location

WIEN, AUSTRIA

ISBN

0043-5325

Periodical

WIENER KLINISCHE WOCHENSCHRIFT

Year of study

128

Number

15-16

State

Republic of Austria

Pages from

592

Pages to

598

Pages count

7

URL

http://apps.webofknowledge.com/full_record.do?product=WOS&search_mode=GeneralSearch&qid=1&SID=N2BUl2cSrhFp7VIrdwT&page=1&doc=5

BibTex

@article{BUT131475,
  author="Bielakova, K and Fernandova, E and Matejovska-Kubesova, H and Weber, P and Prudius, D and Bednar, J",
  title="Can we improve the therapy of Clostridium difficile infection in elderly patients?",
  journal="WIENER KLINISCHE WOCHENSCHRIFT",
  year="2016",
  volume="128",
  number="15-16",
  pages="592--598",
  doi="10.1007/s00508-016-1056-z",
  issn="0043-5325",
  url="http://apps.webofknowledge.com/full_record.do?product=WOS&search_mode=GeneralSearch&qid=1&SID=N2BUl2cSrhFp7VIrdwT&page=1&doc=5"
}