Publication detail

The effect of hydroxyapatite particle size on viscoelastic properties and calcium release from a thermosensitive triblock copolymer

CHAMRADOVÁ, I. VOJTOVÁ, L. ČÁSTKOVÁ, K. DIVIŠ, P. PETEREK, M. JANČÁŘ, J.

Original Title

The effect of hydroxyapatite particle size on viscoelastic properties and calcium release from a thermosensitive triblock copolymer

English Title

The effect of hydroxyapatite particle size on viscoelastic properties and calcium release from a thermosensitive triblock copolymer

Type

journal article in Web of Science

Language

en

Original Abstract

Well-defined Bsmart^ injectable hydrogel based on hydrophilic poly(ethylene glycol) (PEG) and hydrophobic poly(lactic acid-co-glycolic acid) (PLA/PGA) copolymer (PLGA-PEG-PLGA) gelling at the body temperature was modified by bioactive hydroxyapatite (HAp) in the form of micro-, nano-, and core-shell particles (μ-HAp, n-HAp, and CS-x, respectively) to be applicable as calcium delivery system in bone regeneration. Viscoelastic moduli increased with HAp content as expected. Whereas systems containing μ-HAp or CS-x particles maintained two sol-gel and gel-sol phase transitions, the n-HAp containing system showed only one sol-gel phase transition due to the strong interactions between polymer chain and the n-HAp surface. In vitro, studies proved the controlled uniform release of calcium cations from both CS-x and n-HAp over the 9-day period without any initial burst release.

English abstract

Well-defined Bsmart^ injectable hydrogel based on hydrophilic poly(ethylene glycol) (PEG) and hydrophobic poly(lactic acid-co-glycolic acid) (PLA/PGA) copolymer (PLGA-PEG-PLGA) gelling at the body temperature was modified by bioactive hydroxyapatite (HAp) in the form of micro-, nano-, and core-shell particles (μ-HAp, n-HAp, and CS-x, respectively) to be applicable as calcium delivery system in bone regeneration. Viscoelastic moduli increased with HAp content as expected. Whereas systems containing μ-HAp or CS-x particles maintained two sol-gel and gel-sol phase transitions, the n-HAp containing system showed only one sol-gel phase transition due to the strong interactions between polymer chain and the n-HAp surface. In vitro, studies proved the controlled uniform release of calcium cations from both CS-x and n-HAp over the 9-day period without any initial burst release.

Keywords

Polymer composites; Smart polymers; Rheology; Hydroxyapatite; Core-shell particles;sol-gel transition

Released

02.01.2017

Publisher

Springer Berlin Heidelberg

Location

Německo

Pages from

107

Pages to

115

Pages count

9

URL

BibTex


@article{BUT130216,
  author="Ivana {Chamradová} and Lucy {Vojtová} and Klára {Částková} and Pavel {Diviš} and Miroslav {Peterek} and Josef {Jančář}",
  title="The effect of hydroxyapatite particle size on viscoelastic properties and calcium release from a thermosensitive triblock copolymer",
  annote="Well-defined Bsmart^ injectable hydrogel based on hydrophilic poly(ethylene glycol) (PEG) and hydrophobic poly(lactic acid-co-glycolic acid) (PLA/PGA) copolymer (PLGA-PEG-PLGA) gelling at the body temperature was
modified by bioactive hydroxyapatite (HAp) in the form of micro-, nano-, and core-shell particles (μ-HAp, n-HAp, and CS-x, respectively) to be applicable as calcium delivery system in bone regeneration. Viscoelastic moduli increased with HAp content as expected. Whereas systems containing μ-HAp or CS-x particles maintained two sol-gel and gel-sol phase transitions, the n-HAp containing system showed only
one sol-gel phase transition due to the strong interactions between polymer chain and the n-HAp surface. In vitro, studies proved the controlled uniform release of calcium cations from both CS-x and n-HAp over the 9-day period without any initial burst release.",
  address="Springer Berlin Heidelberg",
  chapter="130216",
  doi="10.1007/s00396-016-3983-7",
  howpublished="online",
  institution="Springer Berlin Heidelberg",
  number="1",
  volume="295",
  year="2017",
  month="january",
  pages="107--115",
  publisher="Springer Berlin Heidelberg",
  type="journal article in Web of Science"
}