Publication detail

Prolonged QT Interval in Neurodevelopmental Rat Model of Schizophrenia

STRAČINA, T. RONZHINA, M. STARK, T. RUDA, J. OLŠANSKÁ, E. VESELÝ, P. MICALE, V. NOVÁKOVÁ, M.

Original Title

Prolonged QT Interval in Neurodevelopmental Rat Model of Schizophrenia

Type

conference paper

Language

English

Original Abstract

QT prolongation is an independent risk factor for development of ventricular arrhythmias and eventually sudden cardiac death. It is common side effect of various medications, including antipsychotics. It was reported that schizophrenic patients treated with antipsychotics (e.g. haloperidol, olanzapine) manifested QT prolongation. Also, drug-free schizophrenic patients have increased QT interval compared to healthy controls. Possible mechanisms of QT prolongation connected with schizophrenia are still unclear. The present study on isolated hearts clearly shows that rats with schizophrenia-like phenotype manifest significantly lengthened QT interval as compared to controls. This difference was further increased after acute haloperidol administration. These data indicate that methylazoxymethanol acetate rat model of schizophrenia may be applicable tool for studying of connection between schizophrenia and QT prolongation.

Keywords

Rat isolated heart; electrogram; QT interval; heart rate; arrhythmia; schizophrenia; haloperidol

Authors

STRAČINA, T.; RONZHINA, M.; STARK, T.; RUDA, J.; OLŠANSKÁ, E.; VESELÝ, P.; MICALE, V.; NOVÁKOVÁ, M.

Released

15. 11. 2016

ISBN

978-1-5090-0895-7

Book

Computing in Cardiology Conference

Edition number

43

Pages from

1049

Pages to

1052

Pages count

4

URL

https://ieeexplore.ieee.org/document/7868926

BibTex

@inproceedings{BUT129342,
  author="Tibor {Stračina} and Marina {Filipenská} and Tibor {Stark} and Jana {Ruda} and Eva {Olšanská} and Petr {Veselý} and Vincenzo {Micale} and Marie {Nováková}",
  title="Prolonged QT Interval in Neurodevelopmental Rat Model of Schizophrenia",
  booktitle="Computing in Cardiology Conference",
  year="2016",
  number="43",
  pages="1049--1052",
  isbn="978-1-5090-0895-7",
  url="https://ieeexplore.ieee.org/document/7868926"
}