Publication detail

Stable Gelatin Nanofibers Modified with Oxidized Cellulose for Soft Tissue Engineering

ŠVACHOVÁ, V. VOJTOVÁ, L. JURTÍKOVÁ, V. HAMPL, A. PAVLIŇÁK, D.

Original Title

Stable Gelatin Nanofibers Modified with Oxidized Cellulose for Soft Tissue Engineering

English Title

Stable Gelatin Nanofibers Modified with Oxidized Cellulose for Soft Tissue Engineering

Type

abstract

Language

en

Original Abstract

The present work deals with the preparation of (bio) polymer nanofibers by Nanospider technology. The obtained nanofibers are biocompatible, bioadhesive, porous and mimic the structure of the extracellular matrix forming the structure of tissues. Gelatin nanofibers modified by addition of sodium or calcium salt of oxidized cellulose were successfully prepared. Gelatin is a biocompatible and biodegradable polymer. Oxidized cellulose and its salts are biocompatible, biodegradable and they also exhibit hemostatic and bactericidal efficiency. Crosslinking process was an another important step to improve hydrolytic stability and mechanical properties of nanofibers. H441 cell lines (human papillary adenocarcinoma cells) were seeded on prepared electrospun nanofibers. The viability of H441 cell lines on nanofibers was evaluated. Newly prepared material may have a potential application in surgery and regenerative medicine of soft tissues (e. g. decubitus and burns). 

English abstract

The present work deals with the preparation of (bio) polymer nanofibers by Nanospider technology. The obtained nanofibers are biocompatible, bioadhesive, porous and mimic the structure of the extracellular matrix forming the structure of tissues. Gelatin nanofibers modified by addition of sodium or calcium salt of oxidized cellulose were successfully prepared. Gelatin is a biocompatible and biodegradable polymer. Oxidized cellulose and its salts are biocompatible, biodegradable and they also exhibit hemostatic and bactericidal efficiency. Crosslinking process was an another important step to improve hydrolytic stability and mechanical properties of nanofibers. H441 cell lines (human papillary adenocarcinoma cells) were seeded on prepared electrospun nanofibers. The viability of H441 cell lines on nanofibers was evaluated. Newly prepared material may have a potential application in surgery and regenerative medicine of soft tissues (e. g. decubitus and burns). 

Keywords

Nanospider, nanofibers, gelatin, crosslinking, oxycellulose

Released

01.09.2015

Publisher

Brno University of Technology, Faculty of Chemistry

Location

Brno

ISBN

978-80-214-5228-2

Book

Chemistry & Life 2015 – Book of Abstracts

Edition

First

Pages from

183

Pages to

183

Pages count

1

URL

BibTex


@misc{BUT117059,
  author="Veronika {Pavliňáková} and Lucy {Vojtová} and Veronika {Jurtíková} and Aleš {Hampl} and David {Pavliňák}",
  title="Stable Gelatin Nanofibers Modified with Oxidized Cellulose for Soft
Tissue Engineering",
  annote="The present work deals with the preparation of (bio) polymer nanofibers by Nanospider
technology. The obtained nanofibers are biocompatible, bioadhesive, porous and mimic the
structure of the extracellular matrix forming the structure of tissues. Gelatin nanofibers
modified by addition of sodium or calcium salt of oxidized cellulose were successfully
prepared. Gelatin is a biocompatible and biodegradable polymer. Oxidized cellulose and its
salts are biocompatible, biodegradable and they also exhibit hemostatic and bactericidal
efficiency. Crosslinking process was an another important step to improve hydrolytic
stability and mechanical properties of nanofibers. H441 cell lines (human papillary
adenocarcinoma cells) were seeded on prepared electrospun nanofibers. The viability of
H441 cell lines on nanofibers was evaluated. Newly prepared material may have a potential
application in surgery and regenerative medicine of soft tissues (e. g. decubitus and burns). ",
  address="Brno University of Technology, Faculty of Chemistry",
  booktitle="Chemistry & Life 2015 – Book of Abstracts",
  chapter="117059",
  edition="First",
  howpublished="online",
  institution="Brno University of Technology, Faculty of Chemistry",
  year="2015",
  month="september",
  pages="183--183",
  publisher="Brno University of Technology, Faculty of Chemistry",
  type="abstract"
}