Publication detail

Continuum-based modeling approaches to cell mechanics.

BANSOD, Y. BURŠA, J.

Original Title

Continuum-based modeling approaches to cell mechanics.

English Title

Continuum-based modeling approaches to cell mechanics.

Type

journal article - other

Language

en

Original Abstract

The quantitative study of cell mechanics is of paramount interest, since it regulates the behavior of the living cells in response to the myriad of extracellular and intracellular mechanical stimuli. The novel experimental techniques together with robust computational approaches have given rise to new theories and models, which describe cell mechanics as combination of biomechanical and biochemical processes. This review paper encapsulates the existing continuum-based computational approaches that have been developed for interpreting the mechanical responses of living cells under different loading and boundary conditions. The salient features and drawbacks of each model are discussed from both structural and biological points of view. This discussion can contribute to the development of even more precise and realistic computational models of cell mechanics based on continuum approaches or on their combination with microstructural approaches, which in turn may provide a better understanding of mechanotransduction in living cells.

English abstract

The quantitative study of cell mechanics is of paramount interest, since it regulates the behavior of the living cells in response to the myriad of extracellular and intracellular mechanical stimuli. The novel experimental techniques together with robust computational approaches have given rise to new theories and models, which describe cell mechanics as combination of biomechanical and biochemical processes. This review paper encapsulates the existing continuum-based computational approaches that have been developed for interpreting the mechanical responses of living cells under different loading and boundary conditions. The salient features and drawbacks of each model are discussed from both structural and biological points of view. This discussion can contribute to the development of even more precise and realistic computational models of cell mechanics based on continuum approaches or on their combination with microstructural approaches, which in turn may provide a better understanding of mechanotransduction in living cells.

Keywords

Cell mechanics, computational models, continuum approach, mechanical models

RIV year

2015

Released

17.09.2015

Publisher

World Academy of Science, Engineering and Technology, International Science

Location

Rome, Italy

Pages from

1202

Pages to

1213

Pages count

12

Documents

BibTex


@article{BUT115976,
  author="Yogesh Deepak {Bansod} and Jiří {Burša}",
  title="Continuum-based modeling approaches to cell mechanics.",
  annote="The quantitative study of cell mechanics is of paramount interest, since it regulates the behavior of the living cells in response to the myriad of extracellular and intracellular mechanical stimuli. The novel experimental techniques together with robust computational approaches have given rise to new theories and models, which describe cell mechanics as combination of biomechanical and biochemical processes. This review paper
encapsulates the existing continuum-based computational approaches that have been developed for interpreting the mechanical responses of living cells under different loading and boundary conditions. The
salient features and drawbacks of each model are discussed from both structural and biological points of view. This discussion can contribute to the development of even more precise and realistic computational models of cell mechanics based on continuum approaches or on their combination with microstructural approaches,
which in turn may provide a better understanding of mechanotransduction in living cells.",
  address="World Academy of Science, Engineering and Technology, International Science",
  booktitle="17th International Conference on Cell and Stem Cell Engineering.",
  chapter="115976",
  howpublished="online",
  institution="World Academy of Science, Engineering and Technology, International Science",
  number="9",
  volume="2",
  year="2015",
  month="september",
  pages="1202--1213",
  publisher="World Academy of Science, Engineering and Technology, International Science",
  type="journal article - other"
}