Publication detail

Natural polysaccharide Gum Karaya as novel biomaterial in regenerative medicine

POŠTULKOVÁ, H. VOJTOVÁ, L. JANČÁŘ, J.

Original Title

Natural polysaccharide Gum Karaya as novel biomaterial in regenerative medicine

English Title

Natural polysaccharide Gum Karaya as novel biomaterial in regenerative medicine

Type

abstract

Language

en

Original Abstract

Natural polysaccharides are biodegradable, freely available, relatively cheap and nontoxic materials with great potential in medical applications. The polysaccharide hydrogels supports wound healing by providing moist environment and can be utilized as wound dressing for soft tissue regeneration (e.g. skin burns or ulcers). One suitable candidate is Gum Karaya (GK), anionic polysaccharide containing β-D-galactose, L-rhamnose, β-D-glucuronic acid and D-galacturonic acid. Natural GK is partially acetylated high molecular weight polymer (Mw ≈ 9 mil Da), water insoluble, having high swelling and retention capacity, high viscosity and inherent antimicrobial activity. [1, 2, 3] The objective of this study is to prepare a soluble sample of GK by alkali treatment followed by designing new procedure for GK hydrogel preparation which meets requirements for use as wound healing coverings. Prepared samples were characterized by SEM, FTIR, NMR, TGA, DSC and rheology.

English abstract

Natural polysaccharides are biodegradable, freely available, relatively cheap and nontoxic materials with great potential in medical applications. The polysaccharide hydrogels supports wound healing by providing moist environment and can be utilized as wound dressing for soft tissue regeneration (e.g. skin burns or ulcers). One suitable candidate is Gum Karaya (GK), anionic polysaccharide containing β-D-galactose, L-rhamnose, β-D-glucuronic acid and D-galacturonic acid. Natural GK is partially acetylated high molecular weight polymer (Mw ≈ 9 mil Da), water insoluble, having high swelling and retention capacity, high viscosity and inherent antimicrobial activity. [1, 2, 3] The objective of this study is to prepare a soluble sample of GK by alkali treatment followed by designing new procedure for GK hydrogel preparation which meets requirements for use as wound healing coverings. Prepared samples were characterized by SEM, FTIR, NMR, TGA, DSC and rheology.

Keywords

natural gum, polysaccharide, gum karaya, chemical modification, characterization, solubility

Released

02.09.2015

Publisher

CEITEC

Location

Brno

Pages from

132

Pages to

132

Pages count

1

URL

BibTex


@misc{BUT115916,
  author="Hana {Poštulková} and Lucy {Vojtová} and Josef {Jančář}",
  title="Natural polysaccharide Gum Karaya as novel biomaterial in regenerative medicine",
  annote="Natural polysaccharides are biodegradable, freely available, relatively cheap and nontoxic materials with great potential in medical applications. The polysaccharide hydrogels supports wound healing by providing moist environment and can be utilized as wound dressing for soft tissue regeneration (e.g. skin burns or ulcers). 
One suitable candidate is Gum Karaya (GK), anionic polysaccharide containing β-D-galactose, L-rhamnose, β-D-glucuronic acid and D-galacturonic acid. Natural GK is partially acetylated high molecular weight polymer (Mw ≈ 9 mil Da), water insoluble, having high swelling and retention capacity, high viscosity and inherent antimicrobial activity. [1, 2, 3]
The objective of this study is to prepare a soluble sample of GK by alkali treatment followed by designing new procedure for GK hydrogel preparation which meets requirements for use as wound healing coverings. Prepared samples were characterized by SEM, FTIR, NMR, TGA, DSC and rheology.
",
  address="CEITEC",
  chapter="115916",
  doi="10.1371/journal.pone.0100028",
  howpublished="online",
  institution="CEITEC",
  year="2015",
  month="september",
  pages="132--132",
  publisher="CEITEC",
  type="abstract"
}