Publication detail
Colloid Properties of Phospholipids Aggregates
PILGROVÁ, T. MRAVEC, F. GREGOROVÁ, Z. ORBAN, M. PEKAŘ, M.
Original Title
Colloid Properties of Phospholipids Aggregates
English Title
Colloid Properties of Phospholipids Aggregates
Type
abstract
Language
en
Original Abstract
Microbubbles are used as contrast agents in combination with ultrasound mostly for cardiovascular imaging or the assessment of perfusion of various organs and tumors. The aim of our study was to evaluate ability of solubilization and formation process of microbubble SonoVue phospholipid liposomes and surfactant micelles as basis for development of new contrast agent for drug delivery applications. Ability of solubilization was study using the UV-VIS spectroscopy and solubilizing capacity was determined using hydrophobic solutes because of obtaining a model system of solubilized drugs or vitamins which are also hydrophobic. Microbubble and liposomes formation process was investigated using surface tension measurements, specifically maximum bubble pressure method.
English abstract
Microbubbles are used as contrast agents in combination with ultrasound mostly for cardiovascular imaging or the assessment of perfusion of various organs and tumors. The aim of our study was to evaluate ability of solubilization and formation process of microbubble SonoVue phospholipid liposomes and surfactant micelles as basis for development of new contrast agent for drug delivery applications. Ability of solubilization was study using the UV-VIS spectroscopy and solubilizing capacity was determined using hydrophobic solutes because of obtaining a model system of solubilized drugs or vitamins which are also hydrophobic. Microbubble and liposomes formation process was investigated using surface tension measurements, specifically maximum bubble pressure method.
Keywords
Colloid, phospholipids, aggregates
Released
18.09.2014
Location
Shanghai, China
Pages from
116
Pages to
117
Pages count
2
BibTex
@misc{BUT110489,
author="Tereza {Pilgrová} and Filip {Mravec} and Zdeňka {Gregorová} and Marek {Orban} and Miloslav {Pekař}",
title="Colloid Properties of Phospholipids Aggregates",
annote="Microbubbles are used as contrast agents in combination with ultrasound mostly for cardiovascular imaging or the assessment of perfusion of various organs and tumors. The aim of our study was to evaluate ability of solubilization and formation process of microbubble SonoVue phospholipid liposomes and surfactant micelles as basis for development of new contrast agent for drug delivery applications. Ability of solubilization was study using the UV-VIS spectroscopy and solubilizing capacity was determined using hydrophobic solutes because of obtaining a model system of solubilized drugs or vitamins which are also hydrophobic. Microbubble and liposomes formation process was investigated using surface tension measurements, specifically maximum bubble pressure method.",
chapter="110489",
year="2014",
month="september",
pages="116--117",
type="abstract"
}