Publication detail

Colloid Properties of Phospholipids Aggregates

PILGROVÁ, T. MRAVEC, F. GREGOROVÁ, Z. ORBAN, M. PEKAŘ, M.

Original Title

Colloid Properties of Phospholipids Aggregates

English Title

Colloid Properties of Phospholipids Aggregates

Type

abstract

Language

en

Original Abstract

Microbubbles are used as contrast agents in combination with ultrasound mostly for cardiovascular imaging or the assessment of perfusion of various organs and tumors. The aim of our study was to evaluate ability of solubilization and formation process of microbubble SonoVue phospholipid liposomes and surfactant micelles as basis for development of new contrast agent for drug delivery applications. Ability of solubilization was study using the UV-VIS spectroscopy and solubilizing capacity was determined using hydrophobic solutes because of obtaining a model system of solubilized drugs or vitamins which are also hydrophobic. Microbubble and liposomes formation process was investigated using surface tension measurements, specifically maximum bubble pressure method.

English abstract

Microbubbles are used as contrast agents in combination with ultrasound mostly for cardiovascular imaging or the assessment of perfusion of various organs and tumors. The aim of our study was to evaluate ability of solubilization and formation process of microbubble SonoVue phospholipid liposomes and surfactant micelles as basis for development of new contrast agent for drug delivery applications. Ability of solubilization was study using the UV-VIS spectroscopy and solubilizing capacity was determined using hydrophobic solutes because of obtaining a model system of solubilized drugs or vitamins which are also hydrophobic. Microbubble and liposomes formation process was investigated using surface tension measurements, specifically maximum bubble pressure method.

Keywords

Colloid, phospholipids, aggregates

Released

18.09.2014

Location

Shanghai, China

Pages from

116

Pages to

117

Pages count

2

BibTex


@misc{BUT110489,
  author="Tereza {Pilgrová} and Filip {Mravec} and Zdeňka {Gregorová} and Marek {Orban} and Miloslav {Pekař}",
  title="Colloid Properties of Phospholipids Aggregates",
  annote="Microbubbles are used as contrast agents in combination with ultrasound mostly for cardiovascular imaging or the assessment of perfusion of various organs and tumors. The aim of our study was to evaluate ability of solubilization and formation process of microbubble SonoVue phospholipid liposomes and surfactant micelles as basis for development of new contrast agent for drug delivery applications. Ability of solubilization was study using the UV-VIS spectroscopy and solubilizing capacity was determined using hydrophobic solutes because of obtaining a model system of solubilized drugs or vitamins which are also hydrophobic. Microbubble and liposomes formation process was investigated using surface tension measurements, specifically maximum bubble pressure method.",
  chapter="110489",
  year="2014",
  month="september",
  pages="116--117",
  type="abstract"
}