Publication detail

Synthesis, characterization and antibacterial activity of new fluorescent chitosan derivatives

PŘICHYSTALOVÁ, H. ALMONASY, N. ABDEL-LATTIF, A. ABDEL-RAHMAN, R. FOUDA, M. VOJTOVÁ, L. KOBĚRA, L. SPOTZ, Z. BURGERT, L. JANČÁŘ, J.

Original Title

Synthesis, characterization and antibacterial activity of new fluorescent chitosan derivatives

English Title

Synthesis, characterization and antibacterial activity of new fluorescent chitosan derivatives

Type

journal article in Web of Science

Language

en

Original Abstract

The present work aims to the development of innovative new derivatives of chitosan that can be used for medical applications. This innovation is based on the synthesis and characterization of chitosan-g-aminoanthracene derivatives. Thus, N-(anthracen-9-yl)-4,6- dichloro-[1,3,5]-triazin-2-amine (AT) reacted with chitosan by the following steps: At first, cyanuric chloride reacted with 9-aminoanthracene to obtain N-(anthracen-9-yl)-4,6-dichloro- 40 [1,3,5]-triazin-2-amine (AT), then the AT reacted with chitosan to obtain (CH -g-AT). The final product of CH-g-AT was separated, purified and re-crystallized by dioxan. The structure of the prepared chitosan derivatives was confirmed by FTIR-ATR, solid-NMR, TGA, X-RD, and DSC. The new chitosan derivatives showed fluorescence spectra in liquid and in solid state as well. CH-g-AT showed also high antibacterial activity against gram-negative species (Escherichia coli).

English abstract

The present work aims to the development of innovative new derivatives of chitosan that can be used for medical applications. This innovation is based on the synthesis and characterization of chitosan-g-aminoanthracene derivatives. Thus, N-(anthracen-9-yl)-4,6- dichloro-[1,3,5]-triazin-2-amine (AT) reacted with chitosan by the following steps: At first, cyanuric chloride reacted with 9-aminoanthracene to obtain N-(anthracen-9-yl)-4,6-dichloro- 40 [1,3,5]-triazin-2-amine (AT), then the AT reacted with chitosan to obtain (CH -g-AT). The final product of CH-g-AT was separated, purified and re-crystallized by dioxan. The structure of the prepared chitosan derivatives was confirmed by FTIR-ATR, solid-NMR, TGA, X-RD, and DSC. The new chitosan derivatives showed fluorescence spectra in liquid and in solid state as well. CH-g-AT showed also high antibacterial activity against gram-negative species (Escherichia coli).

Keywords

chitosan, antibacterial activity, fluorescent derivatives

RIV year

2014

Released

01.04.2014

Pages from

234

Pages to

240

Pages count

580

BibTex


@article{BUT105081,
  author="Hana {Přichystalová} and Numan {Almonasy} and Abdelmohsan {Abdellatif} and Rasha M. {Abdel-Rahman} and Moustafa M.D. {Fouda} and Lucy {Vojtová} and Libor {Koběra} and Zdeněk {Spotz} and Ladislav {Burgert} and Josef {Jančář}",
  title="Synthesis, characterization and antibacterial activity of new fluorescent chitosan derivatives",
  annote="The present work aims to the development of innovative new derivatives of chitosan
that can be used for medical applications. This innovation is based on the synthesis and
characterization of chitosan-g-aminoanthracene derivatives. Thus, N-(anthracen-9-yl)-4,6-
dichloro-[1,3,5]-triazin-2-amine (AT) reacted with chitosan by the following steps: At first,
cyanuric chloride reacted with 9-aminoanthracene to obtain N-(anthracen-9-yl)-4,6-dichloro-
40 [1,3,5]-triazin-2-amine (AT), then the AT reacted with chitosan to obtain (CH -g-AT). The
 final product of CH-g-AT was separated, purified and re-crystallized by dioxan. The structure
 of the prepared chitosan derivatives was confirmed by FTIR-ATR, solid-NMR, TGA, X-RD,
and DSC. The new chitosan derivatives showed fluorescence spectra in liquid and in solid
state as well. CH-g-AT showed also high antibacterial activity against gram-negative species
(Escherichia coli).",
  chapter="105081",
  doi="10.1016/j.ijbiomac.2014.01.050",
  number="1",
  volume="65",
  year="2014",
  month="april",
  pages="234--240",
  type="journal article in Web of Science"
}