Publication detail

Single-channel blind estimation of arterial input function and tissue impulse response in DCE-MRI.

TAXT, T. JIŘÍK, R. RYGH, C. GRÜNER, R. BARTOŠ, M. ANDERSEN, E. CURRY, F. REED, R.

Original Title

Single-channel blind estimation of arterial input function and tissue impulse response in DCE-MRI.

Type

journal article in Web of Science

Language

English

Original Abstract

Multipass dynamic MRI and pharmacokinetic modeling are used to estimate perfusion parameters of leaky capillaries. Curve fitting and nonblind deconvolution are the established methods to derive the perfusion estimates from the observed arterial input function (AIF) and tissue tracer concentration function. These nonblind methods are sensitive to errors in the AIF, measured in some nearby artery or estimated by multichannel blind deconvolution. Here, a single-channel blind deconvolution algorithm is presented, which only uses a single tissue tracer concentration function to estimate the corresponding AIF and tissue impulse response function. That way, many errors affecting these functions are reduced. The validity of the algorithm is supported by simulations and tests on real data from mouse. The corresponding nonblind and multichannel methods are also presented.

Keywords

Perfusion, DCE-MRI, blind deconvolution, arterial input function, single-channel, multi-channel

Authors

TAXT, T.; JIŘÍK, R.; RYGH, C.; GRÜNER, R.; BARTOŠ, M.; ANDERSEN, E.; CURRY, F.; REED, R.

RIV year

2012

Released

1. 4. 2012

ISBN

0018-9294

Periodical

IEEE TRANSACTIONS ON BIOMEDICAL ENGINEERING

Year of study

59

Number

4

State

United States of America

Pages from

1012

Pages to

1021

Pages count

10

BibTex

@article{BUT94726,
  author="Torfinn {Taxt} and Radovan {Jiřík} and Cecilie Brekke {Rygh} and Renate {Grüner} and Michal {Bartoš} and Erling {Andersen} and Fitz-Roy {Curry} and Rolf {Reed}",
  title="Single-channel blind estimation of arterial input function and tissue impulse response in DCE-MRI.",
  journal="IEEE TRANSACTIONS ON BIOMEDICAL ENGINEERING",
  year="2012",
  volume="59",
  number="4",
  pages="1012--1021",
  issn="0018-9294"
}