Publication detail

Suggestion of electrochemical sensors for microanalysis of content of copper in biological samples

HUBÁLEK, J. DUŠA, F. FABRIK, I. HÚSKA, D. KIZEK, R. JELEN, F. TRNKOVÁ, L.

Original Title

Suggestion of electrochemical sensors for microanalysis of content of copper in biological samples

Type

journal article - other

Language

English

Original Abstract

There have been published several papers on voltammetric ultra-trace determination of some nucleic bases in the presence of Cu(II) using a mercury electrode or solid amalgam electrodes. Carbon electrodes can be used for the same purposes. The aim of this work was to employ the behaviour of purines in the presence of Cu(II) to determine these metal ions. Primarily we aimed on investigation of basic electrochemical behaviour of detection copper at hanging mercury drop and carbon paste electrodes by using of cyclic and differential pulse voltammetry. Thanks to formation of the complex adenine-Cu(II) under the specific conditions the peak of this complex was measured at -0.6 V. The detection limit (3 S/N) for Cu(II) ions was estimated as 5 nM. By using of this approach we were able to determine the content of copper in animal tissues even at tens of nM. Moreover we utilized suggested approach to monitor the level of copper ions in samples of blood serum of patients with metabolic disorder.

Keywords

copper detection, electrochemical sensor, carbon electrode

Authors

HUBÁLEK, J.; DUŠA, F.; FABRIK, I.; HÚSKA, D.; KIZEK, R.; JELEN, F.; TRNKOVÁ, L.

RIV year

2008

Released

26. 10. 2008

Publisher

IEEE

Location

Lecce, Itálie

ISBN

1930-0395

Periodical

The Seventh IEEE Conference on SENSORS

Year of study

2008

Number

7

State

United States of America

Pages from

902

Pages to

905

Pages count

4

BibTex

@article{BUT49157,
  author="HUBÁLEK, J. and DUŠA, F. and FABRIK, I. and HÚSKA, D. and KIZEK, R. and JELEN, F. and TRNKOVÁ, L.",
  title="Suggestion of electrochemical sensors for microanalysis of content of copper in biological samples",
  journal="The Seventh IEEE Conference on SENSORS",
  year="2008",
  volume="2008",
  number="7",
  pages="902--905",
  issn="1930-0395"
}