Publication detail

The Evolution of Action Potential during Repeated Ischemia in Rabbit Myocardium

SEKORA, J. PROVAZNÍK, I. KOLÁŘOVÁ, J. ŠVRČEK, M.

Original Title

The Evolution of Action Potential during Repeated Ischemia in Rabbit Myocardium

Type

journal article - other

Language

English

Original Abstract

Ischemic preconditioning is a technique in which tissue is rendered resistant to the deleterious effects of prolonged ischemia and reperfusion by prior exposure to brief, repeated periods of vascular occlusion [Czech Cardiology Society, Medicine Word]. The hypothesis of ischemic preconditioning was first described at 1986 in [Murray], where it was demonstrated a 75 % reduction in infarct size caused by a 40 min coronary artery occlusion, when the occlusion was preceded by four episodes of 5 min ischemia and 5 min of reperfusion. Cardiac ischemia also causes beat-to-beat fluctuation in action potential duration which leads to T-wave alternans and arrhythmias [Qian]. Other studies describes links between action potenntial prolongation to cardiac alternans [Wilson]. This paper analyse action potentials recorded during repeated global ischemia and reperfusion in the experiment with rabbit hearts and verify the theory of ischemic preconditioning. In the experiment, optical mapping on the myocardium was used. The main principle of this method is an application of fluorescent voltage-sensitive dye, which binds to a membrane of cardiac cells, where it is activated by visible light.

Keywords

Action Potentials, Repeated Ischemia, Rabbit Myocardium

Authors

SEKORA, J.; PROVAZNÍK, I.; KOLÁŘOVÁ, J.; ŠVRČEK, M.

RIV year

2008

Released

30. 6. 2008

Publisher

VUTIUM

Location

Brno

ISBN

1211-412X

Periodical

Analysis of Biomedical Signals and Images

Year of study

19

Number

1

State

Czech Republic

Pages from

1

Pages to

4

Pages count

4

BibTex

@article{BUT47594,
  author="Jiří {Sekora} and Valentine {Provazník} and Jana {Kolářová} and Martin {Švrček}",
  title="The Evolution of Action Potential during Repeated Ischemia in Rabbit Myocardium",
  journal="Analysis of Biomedical Signals and Images",
  year="2008",
  volume="19",
  number="1",
  pages="1--4",
  issn="1211-412X"
}