Publication detail

Influence of ischemia on left ventricular depolarization in isolated rabbit hearts perfused according to Langendorff

KOLÁŘOVÁ, J. JANOUŠEK, O. NOVÁKOVÁ, M. FIALOVÁ, K. PROVAZNÍK, I.

Original Title

Influence of ischemia on left ventricular depolarization in isolated rabbit hearts perfused according to Langendorff

English Title

Influence of ischemia on left ventricular depolarization in isolated rabbit hearts perfused according to Langendorff

Type

conference paper

Language

Czech

Original Abstract

The aim of this study was to search for relation between electrical activity recorded from whole isolated heart and simultaneously from one cell. The QRS complex of elec-trogram (ECG) corresponds to the depolarization of the ven-tricles. The depolarization propagation is shown by monopha-sic action potential (MAP) recorded at appointed place during experiment. Electrogram changes observed during ischemia should be accounted for changes on cellular level. MAPs and ECG were recorded simultaneously. The activation time (AT), defined as distance from the earliest QRS deflection to MAP upstroke, changes with duration of ischemia. The excitement propagation and conduction in ischemic heart takes longer time in comparison to non-ischemic myocardium.

English abstract

The aim of this study was to search for relation between electrical activity recorded from whole isolated heart and simultaneously from one cell. The QRS complex of elec-trogram (ECG) corresponds to the depolarization of the ven-tricles. The depolarization propagation is shown by monopha-sic action potential (MAP) recorded at appointed place during experiment. Electrogram changes observed during ischemia should be accounted for changes on cellular level. MAPs and ECG were recorded simultaneously. The activation time (AT), defined as distance from the earliest QRS deflection to MAP upstroke, changes with duration of ischemia. The excitement propagation and conduction in ischemic heart takes longer time in comparison to non-ischemic myocardium.

Keywords

Electrogram, monophasic action potential, activation time, ischemia, reperfusion, isolated rabbit heart.

Key words in English

Electrogram, monophasic action potential, activation time, ischemia, reperfusion, isolated rabbit heart.

Authors

KOLÁŘOVÁ, J.; JANOUŠEK, O.; NOVÁKOVÁ, M.; FIALOVÁ, K.; PROVAZNÍK, I.

RIV year

2009

Released

7. 9. 2009

Publisher

Springer Berlin

Location

Munich, Germany

ISBN

978-3-642-03897-6

Book

IFMBE Proceeding, Volume 25, World Congress on Medical Physics and Biomedical Engineering

Pages from

1419

Pages to

1422

Pages count

4

BibTex

@inproceedings{BUT31338,
  author="Jana {Kolářová} and Oto {Janoušek} and Marie {Nováková} and Kateřina {Fialová} and Valentine {Provazník}",
  title="Influence of ischemia on left ventricular depolarization in isolated rabbit hearts perfused according to Langendorff",
  booktitle="IFMBE Proceeding, Volume 25, World Congress on Medical Physics and Biomedical Engineering",
  year="2009",
  pages="1419--1422",
  publisher="Springer Berlin",
  address="Munich, Germany",
  isbn="978-3-642-03897-6"
}