Publication detail

In-vitro measurement of aerosol generated by Respimat SMI penetrating through upper airways.

MIŠÍK, O. LÍZAL, F. MALÝ, M. KARAS, J. JEDELSKÝ, J. JÍCHA, M.

Original Title

In-vitro measurement of aerosol generated by Respimat SMI penetrating through upper airways.

English Title

In-vitro measurement of aerosol generated by Respimat SMI penetrating through upper airways.

Language

en

Original Abstract

Respimat soft mist inhaler (SMI) is an inhaler producing a soft mist with low velocity. The liquid drug solution is emitted by the mechanical energy of compressed spring, so the device is propellant-free. This paper describes the measurement of particle fraction penetrating through the model of the upper respiratory tract (mouth cavity, pharynx, larynx trachea). The solution inside the cartridge was marked by fluorescein in order to evaluate the regional particle deposition in the model. After the exposition, segments of the model, as well as the filter, were washed out and the deposited fluorescein was extracted into water. The analysis showed that the fraction of particles penetrating through the upper respiratory tract was 64.7±6.7 %. However, the real inhalation pattern was not simulated and measurement was provided with continual “inhalation” without “exhalation”.

English abstract

Respimat soft mist inhaler (SMI) is an inhaler producing a soft mist with low velocity. The liquid drug solution is emitted by the mechanical energy of compressed spring, so the device is propellant-free. This paper describes the measurement of particle fraction penetrating through the model of the upper respiratory tract (mouth cavity, pharynx, larynx trachea). The solution inside the cartridge was marked by fluorescein in order to evaluate the regional particle deposition in the model. After the exposition, segments of the model, as well as the filter, were washed out and the deposited fluorescein was extracted into water. The analysis showed that the fraction of particles penetrating through the upper respiratory tract was 64.7±6.7 %. However, the real inhalation pattern was not simulated and measurement was provided with continual “inhalation” without “exhalation”.

Keywords

Inhaler, aerosol, deposition, airways

Released

19.11.2019

Location

Františkovy Lázne

Pages from

1

Pages to

4

Pages count

4

Documents

BibTex


@inproceedings{BUT161065,
  author="Ondrej {Mišík} and František {Lízal} and Milan {Malý} and Jakub {Karas} and Jan {Jedelský} and Miroslav {Jícha}",
  title="In-vitro measurement of aerosol generated by Respimat SMI penetrating through upper airways.",
  annote="Respimat soft mist inhaler (SMI) is an inhaler producing a soft mist with low velocity. The liquid drug solution is emitted by the mechanical energy of compressed spring, so the device is propellant-free. This paper describes the measurement of particle fraction penetrating through the model of the upper respiratory tract (mouth cavity, pharynx, larynx trachea). The solution inside the cartridge was marked by fluorescein in order to evaluate the regional particle deposition in the model. After the exposition, segments of the model, as well as the filter, were washed out and the deposited fluorescein was extracted into water. The analysis showed that the fraction of particles penetrating through the upper respiratory tract was 64.7±6.7 %. However, the real inhalation pattern was not simulated and measurement was provided with continual “inhalation” without “exhalation”.",
  chapter="161065",
  howpublished="online",
  year="2019",
  month="november",
  pages="1--4"
}