Semi-Quantitative Abstraction and Analysis of Chemical Reaction Networks

conference paper

English

Analysis of large continuous-time stochastic systems is a computationally intensive task. In this work we focus on population models arising from chemical reaction networks (CRNs), which play a fundamental role in analysis and design of biochemical systems. Many relevant CRNs are particularly challenging for existing techniques due to complex dynamics including stochasticity, stiffness or multimodal population distributions. We propose a novel approach allowing not only to predict, but also to explain both the transient and steady-state behaviour. It focuses on qualitative description of the behaviour and aims at quantitative precision only in orders of magnitude. First we build a compact understandable model, which we then crudely analyse. As demonstrated on complex CRNs from literature, our approach reproduces the known results, but in contrast to the state-of-the-art methods, it runs with virtually no computational cost and thus offers unprecedented scalability.

chemical reaction networks, continuous-time Markov chains, population level abstraction, semiquantitative reasoning 

ČEŠKA, M.; KŘETÍNSKÝ, J.

17. 4. 2019

Springer International Publishing

New York

978-3-030-25540-4

Proceedings of the 31th International Conference on Computer Aided Verification (CAV'19)

Lecture Notes of Computer Science

475

496

22