Publication detail

Effect of surfactants and polymers on stability of superparamagnetic nanoparticles and on immobilization and release of antitumor agents

BUCHTELOVÁ, H. ŠKUBALOVÁ, Z. KUDR, J. STRMISKA, V. ADAM, V. HEGER, Z.

Original Title

Effect of surfactants and polymers on stability of superparamagnetic nanoparticles and on immobilization and release of antitumor agents

Type

conference paper

Language

English

Original Abstract

The current study demonstrates design, preparation and characterization of biocompatible superparamagnetic iron oxide nanoparticles (SPIONs) coated with three different polymers polyvinylpyrrolidone (PVP) polyoxyethylene stearate (POES) and chitosan (Chit). Such modified nanoparticles were loaded with doxorubicin, as model anticancer drug. Resulting complex has an exceptional stability in physiological conditions. The highest release of complexed Dox was in endosomal environment in case SPIONs with POES. The cytotoxic effects of the complex were tested using breast cancer/healthy epithelial cell lines. Use of SPIONs increased the cytotoxicity of doxorubicin when compared to free doxorubicin and decreased the cytotoxicity in healthy cells. The results demonstrate that modification of SPIONs could have a potential in nanomedicine as versatile nanoplatform to enhance efficiency of anticancer therapy.

Keywords

biocompatibility; SPION; nanomedicine; cytotoxicity

Authors

BUCHTELOVÁ, H.; ŠKUBALOVÁ, Z.; KUDR, J.; STRMISKA, V.; ADAM, V.; HEGER, Z.

Released

2. 1. 2019

Publisher

Mendel University in Brno

ISBN

978-80-7509-597-8

Book

MendelNet 2018

Pages from

489

Pages to

494

Pages count

6

URL

https://mendelnet.cz/artkey/mnt-201801-0102_Effect-of-surfactants-and-polymers-on-stability-of-superparamagnetic-nanoparticles-and-on-immobilization-and-re.php?back=/magno/mnt/2018/mn1.php?secid=4

Full text in the Digital Library

http://hdl.handle.net/11012/178380

BibTex

@inproceedings{BUT156233,
  author="Hana {Michálková} and Zuzana {Škubalová} and Jiří {Kudr} and Vladislav {Strmiska} and Vojtěch {Adam} and Zbyněk {Heger}",
  title="Effect of surfactants and polymers on stability of superparamagnetic nanoparticles and on immobilization and release of antitumor agents",
  booktitle="MendelNet 2018",
  year="2019",
  pages="489--494",
  publisher="Mendel University in Brno",
  isbn="978-80-7509-597-8",
  url="https://mendelnet.cz/artkey/mnt-201801-0102_Effect-of-surfactants-and-polymers-on-stability-of-superparamagnetic-nanoparticles-and-on-immobilization-and-re.php?back=/magno/mnt/2018/mn1.php?secid=4"
}