Publication detail

Unique morphogenetic signatures define mammalian neck muscles and associated connective tissues

HEUDE, E. TESAŘOVÁ, M. SEFTON, E. M. JULLIAN, E. ADACHI, N. GRIMALDI, A. ZIKMUND, T. KAISER, J. KARDON, G. KELLY, R. G. TAJBAKHSH, S.

Original Title

Unique morphogenetic signatures define mammalian neck muscles and associated connective tissues

Type

journal article in Web of Science

Language

English

Original Abstract

In vertebrates, head and trunk muscles develop from different mesodermal populations and are regulated by distinct genetic networks. Neck muscles at the head-trunk interface remain poorly defined due to their complex morphogenesis and dual mesodermal origins. Here, we use genetically modified mice to establish a 3D model that integrates regulatory genes, cell populations and morphogenetic events that define this transition zone. We show that the evolutionary conserved cucullaris-derived muscles originate from posterior cardiopharyngeal mesoderm, not lateral plate mesoderm, and we define new boundaries for neural crest and mesodermal contributions to neck connective tissue. Furthermore, lineage studies and functional analysis of Tbx1- and Pax3-null mice reveal a unique developmental program for somitic neck muscles that is distinct from that of somitic trunk muscles. Our findings unveil the embryological and developmental requirements underlying tetrapod neck myogenesis and provide a blueprint to investigate how muscle subsets are selectively affected in some human myopathies.

Keywords

cranial mesoderm, somite, neural crest, neck myogenesis

Authors

HEUDE, E.; TESAŘOVÁ, M.; SEFTON, E. M.; JULLIAN, E.; ADACHI, N.; GRIMALDI, A.; ZIKMUND, T.; KAISER, J.; KARDON, G.; KELLY, R. G.; TAJBAKHSH, S.

Released

19. 11. 2018

ISBN

2050-084X

Periodical

eLife

Number

7

State

United Kingdom of Great Britain and Northern Ireland

Pages from

1

Pages to

26

Pages count

26

URL

https://elifesciences.org/articles/40179

BibTex

@article{BUT151621,
  author="HEUDE, E. and TESAŘOVÁ, M. and SEFTON, E. M. and JULLIAN, E. and ADACHI, N. and GRIMALDI, A. and ZIKMUND, T. and KAISER, J. and KARDON, G. and KELLY, R. G. and TAJBAKHSH, S.",
  title="Unique morphogenetic signatures define mammalian neck muscles and associated connective tissues",
  journal="eLife",
  year="2018",
  number="7",
  pages="1--26",
  doi="10.7554/eLife.40179",
  issn="2050-084X",
  url="https://elifesciences.org/articles/40179"
}