Publication detail

Comparison of the ATH and 2CXM models using low- and high-molecular-weight contrast agents in DCE-MRI

JIŘÍK, R. TAXT, T. SOUČEK, K. KRATOCHVÍLA, J. MACÍČEK, O. DRAŽANOVÁ, E. STARČUK, Z.

Original Title

Comparison of the ATH and 2CXM models using low- and high-molecular-weight contrast agents in DCE-MRI

English Title

Comparison of the ATH and 2CXM models using low- and high-molecular-weight contrast agents in DCE-MRI

Type

conference paper

Language

en

Original Abstract

In DCE-MRI, tissue contrast-agent (CA) concentration curves are modeled as a convolution of the arterial input function (AIF) and the impulse residue function (IRF). The 2CXM and ATH models are the most widely used advanced IRF models that provide separate estimates of blood flow, Fb, and permeability-surface area product, PS, contrary to the commonly applied Tofts models. No consensus exists on which advanced pharmacokinetic model is better. Simulation-based and blind-deconvolution-based preclinical model comparisons are published. This contribution presents a new model-evaluation method based on high- and low-molecular weight (MW) contrast-agents administered within one examination. Some perfusion parameters are expected to be MW-independent (namely Fb and blood volume—vb), while PS should decrease with increasing MW.

English abstract

In DCE-MRI, tissue contrast-agent (CA) concentration curves are modeled as a convolution of the arterial input function (AIF) and the impulse residue function (IRF). The 2CXM and ATH models are the most widely used advanced IRF models that provide separate estimates of blood flow, Fb, and permeability-surface area product, PS, contrary to the commonly applied Tofts models. No consensus exists on which advanced pharmacokinetic model is better. Simulation-based and blind-deconvolution-based preclinical model comparisons are published. This contribution presents a new model-evaluation method based on high- and low-molecular weight (MW) contrast-agents administered within one examination. Some perfusion parameters are expected to be MW-independent (namely Fb and blood volume—vb), while PS should decrease with increasing MW.

Keywords

DCE-MRI, perfusion, blind deconvolution

Released

01.01.2016

Pages from

447

Pages to

448

Pages count

2

BibTex


@inproceedings{BUT142781,
  author="Radovan {Jiřík} and Torfinn {Taxt} and Jiří {Kratochvíla} and Ondřej {Macíček} and Eva {Dražanová} and Zenon {Starčuk}",
  title="Comparison of the ATH and 2CXM models using low- and high-molecular-weight contrast agents in DCE-MRI",
  annote="In DCE-MRI, tissue contrast-agent (CA) concentration curves are modeled as a convolution of the arterial input function (AIF) and the impulse residue function (IRF). The 2CXM and ATH models are the most widely used advanced IRF models that provide separate estimates of blood flow, Fb, and permeability-surface area product, PS, contrary to the commonly applied Tofts models. No consensus exists on which advanced pharmacokinetic model is better. Simulation-based and blind-deconvolution-based preclinical model comparisons are published. This contribution presents a new model-evaluation method based on high- and low-molecular weight (MW) contrast-agents administered within one examination. Some perfusion parameters are expected to
be MW-independent (namely Fb and blood volume—vb), while PS should decrease with increasing MW.",
  booktitle="MAGMA",
  chapter="142781",
  doi="10.1007/s10334-016-0571-2",
  howpublished="online",
  number="S1",
  year="2016",
  month="january",
  pages="447--448",
  type="conference paper"
}