Publication detail

Analysis of Hemodynamic Related Changes in High Frequency Content of QRS Complex in Working Isolated Rabbit Heart

NOVOTNÁ, P. HEJČ, J. RONZHINA, M. JANOUŠEK, O. STRAČINA, T. OLEJNÍČKOVÁ, V. NOVÁKOVÁ, M. KOLÁŘOVÁ, J.

Original Title

Analysis of Hemodynamic Related Changes in High Frequency Content of QRS Complex in Working Isolated Rabbit Heart

Type

conference paper

Language

English

Original Abstract

Aim: High frequency content of QRS complex (HF-QRS) is thought to be related to local conduction velocity (CV). There also exists the evidence suggesting the coupling between CV and mechanical stretch via so-called mechano-electric feedback. The aim of this study was to investigate possible relationship between left ventricular (LV) load and the most common HF-QRS parameters. Methods: Six isolated rabbit hearts in working mode underwent an experimental protocol consisting of upward and downward steps in preload (8-11 cmH2O). Eight unipolar pseudo-ECGs, left atrial pressure, and flow rate were recorded at fs=10 kHz and 16-bit resolution. QRS complexes from hemodynamically stable experiment phase were clustered, aligned, and decomposed into 3 HF-QRS bands followed by the assessment of power envelope RMS, the tallest peak value and its position. Results: No statistically significant changes associated with LV load alteration were observed in HF-QRS parameter. Conclusion: No evidence of load dependent changes in conduction velocity was found in the study. However, HF signal may represent a complex spatial depolarization behavior. Low sensitivity of used metrics should also be taken into consideration.

Keywords

ventricular repolarization, ventricular load, preload, high-frequency analysis, mechano-electric coupling, dynamic response, isolated heart, working heart

Authors

NOVOTNÁ, P.; HEJČ, J.; RONZHINA, M.; JANOUŠEK, O.; STRAČINA, T.; OLEJNÍČKOVÁ, V.; NOVÁKOVÁ, M.; KOLÁŘOVÁ, J.

Released

30. 9. 2017

Publisher

Computing in Cardiology 2017

Location

Rennes, France

ISBN

978-1-5090-0684-7

Book

Computing in Cardiology 2017

Edition

44

Edition number

1

ISBN

0276-6574

Periodical

Computers in Cardiology

State

United States of America

Pages from

1

Pages to

4

Pages count

4

BibTex

@inproceedings{BUT140440,
  author="Petra {Novotná} and Jakub {Hejč} and Marina {Filipenská} and Oto {Janoušek} and Tibor {Stračina} and Veronika {Olejníčková} and Marie {Nováková} and Jana {Kolářová}",
  title="Analysis of Hemodynamic Related Changes in High Frequency Content of QRS Complex in Working Isolated Rabbit Heart",
  booktitle="Computing in Cardiology 2017",
  year="2017",
  series="44",
  journal="Computers in Cardiology",
  number="1",
  pages="1--4",
  publisher="Computing in Cardiology 2017",
  address="Rennes, France",
  doi="10.22489/CinC.2017.293-442",
  isbn="978-1-5090-0684-7",
  issn="0276-6574"
}