Publication detail

Reduction of doxorubicin-induced cardiotoxicity using nanocarriers: A review

FOJTŮ, M. GUMULEC, J. STRAČINA, T. RAUDENSKÁ, M. SKOTÁKOVÁ, A. VACULOVIČOVÁ, M. ADAM, V. BABULA, P. NOVÁKOVÁ, M. MASAŘÍK, M.

Original Title

Reduction of doxorubicin-induced cardiotoxicity using nanocarriers: A review

Type

journal article in Web of Science

Language

English

Original Abstract

Background: Anthracycline antibiotic doxorubicin (DOX) is a very potent and extensively prescribed chemotherapeutic drug. It is widely utilized in the therapy of variety of haematological and solid tumours, although its administration is commonly accompanied with several severe side effects. The most serious one is a development of dose-dependent and cumulative cardiotoxicity. In the course of time, many strategies have been investigated in order to avoid or at least to diminish DOX-induced cardiac dysfunction; these include reduction of toxic effect by co-administration with iron chelators (dexrazoxane), trastuzumab, taxanes, statins, and ACE-inhibitors. However, the attenuation of cardiotoxic effect is still not satisfactory yet.

Keywords

Doxorubicin; nanoparticles; liposomal; polymeric; protein; gold; cardiotoxicity; nanocarriers

Authors

FOJTŮ, M.; GUMULEC, J.; STRAČINA, T.; RAUDENSKÁ, M.; SKOTÁKOVÁ, A.; VACULOVIČOVÁ, M.; ADAM, V.; BABULA, P.; NOVÁKOVÁ, M.; MASAŘÍK, M.

Released

11. 7. 2017

ISBN

1389-2002

Periodical

CURRENT DRUG METABOLISM

Year of study

18

Number

3

State

United Arab Emirates

Pages from

237

Pages to

263

Pages count

27

BibTex

@article{BUT137709,
  author="Michaela {Fojtů} and Jaromír {Gumulec} and Tibor {Stračina} and Martina {Raudenská} and Anna {Skotáková} and Markéta {Vaculovičová} and Vojtěch {Adam} and Petr {Babula} and Marie {Nováková} and Michal {Masařík}",
  title="Reduction of doxorubicin-induced cardiotoxicity using nanocarriers: A review",
  journal="CURRENT DRUG METABOLISM",
  year="2017",
  volume="18",
  number="3",
  pages="237--263",
  doi="10.2174/1389200218666170105165444",
  issn="1389-2002"
}