Publication detail

Zinc and zinc-containing biomolecules in childhood brain tumors

HRABĚTA, J. ECKSCHLAGER, T. STIBOROVÁ, M. HEGER, Z. KŘÍŽKOVÁ, S. ADAM, V.

Original Title

Zinc and zinc-containing biomolecules in childhood brain tumors

Type

journal article in Web of Science

Language

English

Original Abstract

Zinc ions are essential cofactors of a wide range of enzymes, transcription factors, and other regulatory proteins. Moreover, zinc is also involved in cellular signaling and enzymes inhibition. Zinc dysregulation, deficiency, over-supply, and imbalance in zinc ion transporters regulation are connected with various diseases including cancer. A zinc ion pool is maintained by two types of proteins: (i) zinc-binding proteins, which act as a buffer and intracellular donors of zinc and (ii) zinc transporters responsible for zinc fluxes into/from cells and organelles. The decreased serumzinc ion levels have been identified in patients suffering from various cancer diseases, including head and neck tumors and breast, prostate, liver, and lung cancer. On the contrary, increased zinc ion levels have been found in breast cancer and other malignant tissues. Zinc metalloproteomes of a majority of tumors including brain ones are still not yet fully understood. Current knowledge show that zinc ion levels and detection of certain zinc-containing proteins may be utilized for diagnostic and prognostic purposes. In addition, these proteins can also be promising therapeutic targets. The aim of the present work is an overview of the importance of zinc ions, zinc transporters, and zinccontaining proteins in brain tumors, which are, after leukemia, the second most common type of childhood cancer and the second leading cause of death in children after accidents.

Keywords

Cancer . Childhood brain tumors . Metallothioneins . Zinc metalloenzymes . Zinc transporters

Authors

HRABĚTA, J.; ECKSCHLAGER, T.; STIBOROVÁ, M.; HEGER, Z.; KŘÍŽKOVÁ, S.; ADAM, V.

Released

1. 11. 2016

ISBN

0946-2716

Periodical

JOURNAL OF MOLECULAR MEDICINE-JMM

Year of study

94

Number

11

State

Federal Republic of Germany

Pages from

1199

Pages to

1215

Pages count

17

BibTex

@article{BUT131992,
  author="Jan {Hraběta} and Tomáš {Eckschlager} and Marie {Stiborová} and Zbyněk {Heger} and Soňa {Křížková} and Vojtěch {Adam}",
  title="Zinc and zinc-containing biomolecules in childhood brain tumors",
  journal="JOURNAL OF MOLECULAR MEDICINE-JMM",
  year="2016",
  volume="94",
  number="11",
  pages="1199--1215",
  doi="10.1007/s00109-016-1454-8",
  issn="0946-2716"
}