Publication detail

Improving stability of co-amorphous drug system with addition of PVP

TÜRKEOVÁ, I. ENEV, V. KLUČÁKOVÁ, M.

Original Title

Improving stability of co-amorphous drug system with addition of PVP

Type

conference paper

Language

English

Original Abstract

Approximately 90% of small molecular weight drug candidates under development have poor aqueous solubility.One of the most promising approaches in the development of drug delivery systems to improve the efficacy of new drugs is the conversion of a crystalline drug to its respective amorphous counterpart. In this case we tried used aminoacid as stabilizer and PVP6, 7. As drug we used Indomethacin - poorly water soluble BCS class II drug. Indomethacin is a nonsteroidal anti-inflammatory drug (NSAID) that reduces fever, pain and inflammation. We tried to prepare co-amorphous mixtures with aminoacid and polymer and will see that is working, is stable or not.

Keywords

co-amorphous system, PVP, indomethacin, amorf form

Authors

TÜRKEOVÁ, I.; ENEV, V.; KLUČÁKOVÁ, M.

RIV year

2015

Released

3. 12. 2015

Publisher

Vysoké učení technické v Brně, Fakulta chemická

Location

Brno

ISBN

978-80-214-5290-9

Book

Sborník abstraktů 3. prosince 2015 - Studentská konference Chemie je život

Edition

1

Edition number

1

Pages from

310

Pages to

316

Pages count

7

BibTex

@inproceedings{BUT129222,
  author="Irena {Solná} and Vojtěch {Enev} and Martina {Klučáková}",
  title="Improving stability of co-amorphous drug
system with addition of PVP",
  booktitle="Sborník abstraktů 3. prosince 2015 - Studentská konference Chemie je život",
  year="2015",
  series="1",
  number="1",
  pages="310--316",
  publisher="Vysoké učení technické v Brně, Fakulta chemická",
  address="Brno",
  isbn="978-80-214-5290-9"
}