Publication detail

Perspective of Use of Antiviral Peptides against Influenza Virus

SKALIČKOVÁ, S. HEGER, Z. KREJČOVÁ, L. PEKAŘÍK, V. BASTL, K. JANDA, J. KOSTOLANSKÝ, F. VAŘEČKOVÁ, E. ZÍTKA, O. ADAM, V. KIZEK, R.

Original Title

Perspective of Use of Antiviral Peptides against Influenza Virus

Type

journal article in Web of Science

Language

English

Original Abstract

The threat of a worldwide influenza pandemic has greatly increased over the past decade with the emergence of highly virulent avian influenza strains. The increased frequency of drug-resistant influenza strains against currently available antiviral drugs requires urgent development of new strategies for antiviral therapy, too. The research in the field of therapeutic peptides began to develop extensively in the second half of the 20th century. Since then, the mechanisms of action for several peptides and their antiviral prospect received large attention due to the global threat posed by viruses. Here, we discussed the therapeutic properties of peptides used in influenza treatment. Peptides with antiviral activity against influenza can be divided into three main groups. First, entry blocker peptides such as a Flupep that interact with influenza hemagglutinin, block its binding to host cells and prevent viral fusion. Second, several peptides display virucidal activity, disrupting viral envelopes, e.g., Melittin. Finally, a third set of peptides interacts with the viral polymerase complex and act as viral replication inhibitors such as PB1 derived peptides. Here, we present a review of the current literature describing the antiviral activity, mechanism and future therapeutic potential of these influenza antiviral peptides.

Keywords

cationic peptides; hemagglutinin; influenza virus; membrane fusion; neuraminidase; viral replication

Authors

SKALIČKOVÁ, S.; HEGER, Z.; KREJČOVÁ, L.; PEKAŘÍK, V.; BASTL, K.; JANDA, J.; KOSTOLANSKÝ, F.; VAŘEČKOVÁ, E.; ZÍTKA, O.; ADAM, V.; KIZEK, R.

RIV year

2015

Released

1. 10. 2015

Publisher

MDPI

ISBN

1999-4915

Periodical

VIRUSES-BASEL

Year of study

7

Number

10

State

Swiss Confederation

Pages from

5428

Pages to

5442

Pages count

15

URL

http://www.mdpi.com/1999-4915/7/10/2883

Full text in the Digital Library

http://hdl.handle.net/11012/63721

BibTex

@article{BUT120065,
  author="Sylvie {Skaličková} and Zbyněk {Heger} and Ludmila {Krejčová} and Vladimír {Pekařík} and Karel {Bastl} and Jozef {Janda} and František {Kostolanský} and Eva {Vařečková} and Ondřej {Zítka} and Vojtěch {Adam} and René {Kizek}",
  title="Perspective of Use of Antiviral Peptides against Influenza Virus",
  journal="VIRUSES-BASEL",
  year="2015",
  volume="7",
  number="10",
  pages="5428--5442",
  doi="10.3390/v7102883",
  issn="1999-4915",
  url="http://www.mdpi.com/1999-4915/7/10/2883"
}