Publication detail

Using ASL Method for Monitoring of Brain Perfusion Changes in a Rat Model of Schizophrenia and after Chronic Administration of Aripiprazole

DRAŽANOVÁ, E. GROSSOVÁ, L. PISTOVČÁKOVÁ, J. KHAINAR, A. REGINA, D. KAŠPÁREK, T. STARČUK, Z.

Original Title

Using ASL Method for Monitoring of Brain Perfusion Changes in a Rat Model of Schizophrenia and after Chronic Administration of Aripiprazole

English Title

Using ASL Method for Monitoring of Brain Perfusion Changes in a Rat Model of Schizophrenia and after Chronic Administration of Aripiprazole

Type

conference paper

Language

en

Original Abstract

Animals prenatally exposed to polyriboinosinic–polyribocytidilic acid (poly I:C) can be used to parallel neuropathological abnormalities seen in schizophrenia patients. The aim of this study was to test the utility of Arterial Spin Labeling (ASL) MRI method for the evaluation of perfusion in different brain regions in the developmental poly I:C model of schizophrenia in rats. In these animals we further investigated the effect of chronic administration of the antipsychotic aripiprazole on brain perfusion. In the circle of Willis region, we observed significant (p<0,05) increase of blood perfusion in the poly I:C model of schizophrenia in both males and females, and significantly higher perfusion in males than in females in vehicle-treated controls. Perfusion in hippocampus (in both hemispheres) was found significantly higher in males than in females in both vehicle-treated controls and poly I:C prenatally exposed animals. The significantly increased blood perfusion in the circle of Willis in poly I:C prenatally exposed males was found to persist even after chronic administration of aripiprazole. These results add new data to understanding of antipsychotic effects and demonstrate the viability of the proposed approach of combination of the ASL MRI method and the selected rat model of schizophrenia.

English abstract

Animals prenatally exposed to polyriboinosinic–polyribocytidilic acid (poly I:C) can be used to parallel neuropathological abnormalities seen in schizophrenia patients. The aim of this study was to test the utility of Arterial Spin Labeling (ASL) MRI method for the evaluation of perfusion in different brain regions in the developmental poly I:C model of schizophrenia in rats. In these animals we further investigated the effect of chronic administration of the antipsychotic aripiprazole on brain perfusion. In the circle of Willis region, we observed significant (p<0,05) increase of blood perfusion in the poly I:C model of schizophrenia in both males and females, and significantly higher perfusion in males than in females in vehicle-treated controls. Perfusion in hippocampus (in both hemispheres) was found significantly higher in males than in females in both vehicle-treated controls and poly I:C prenatally exposed animals. The significantly increased blood perfusion in the circle of Willis in poly I:C prenatally exposed males was found to persist even after chronic administration of aripiprazole. These results add new data to understanding of antipsychotic effects and demonstrate the viability of the proposed approach of combination of the ASL MRI method and the selected rat model of schizophrenia.

Keywords

ASL, schizophrenia, poly I:C animal model, rats, aripiprazole

RIV year

2015

Released

25.05.2015

Publisher

Institute of Measurement Science

Location

Bratislava

ISBN

978-80-969672-9-2

Book

10th International Conference on Measurement

Pages from

81

Pages to

84

Pages count

4

URL

BibTex


@inproceedings{BUT117239,
  author="Eva {Dražanová} and Lucie {Krátká} and Jana {Pistovčáková} and Amit {Khainar} and Demlová {Regina} and Tomáš {Kašpárek} and Zenon {Starčuk}",
  title="Using ASL Method for Monitoring of Brain Perfusion Changes in a Rat Model of Schizophrenia and after Chronic Administration of Aripiprazole",
  annote="Animals prenatally exposed to polyriboinosinic–polyribocytidilic acid (poly I:C)
can be used to parallel neuropathological abnormalities seen in schizophrenia patients. The
aim of this study was to test the utility of Arterial Spin Labeling (ASL) MRI method for the
evaluation of perfusion in different brain regions in the developmental poly I:C model of
schizophrenia in rats. In these animals we further investigated the effect of chronic
administration of the antipsychotic aripiprazole on brain perfusion. In the circle of Willis
region, we observed significant (p<0,05) increase of blood perfusion in the poly I:C model of
schizophrenia in both males and females, and significantly higher perfusion in males than in
females in vehicle-treated controls. Perfusion in hippocampus (in both hemispheres) was
found significantly higher in males than in females in both vehicle-treated controls and poly
I:C prenatally exposed animals. The significantly increased blood perfusion in the circle of
Willis in poly I:C prenatally exposed males was found to persist even after chronic
administration of aripiprazole. These results add new data to understanding of antipsychotic
effects and demonstrate the viability of the proposed approach of combination of the ASL MRI
method and the selected rat model of schizophrenia.",
  address="Institute of Measurement Science",
  booktitle="10th International Conference on Measurement",
  chapter="117239",
  howpublished="print",
  institution="Institute of Measurement Science",
  year="2015",
  month="may",
  pages="81--84",
  publisher="Institute of Measurement Science",
  type="conference paper"
}