Publication detail

Investigating the influence of taurine on thiol antioxidant status in Wistar rats with a multi-analytical approach

SOCHOR, J. NEJDL, L. RUTTKAY-NEDECKÝ, B. BEZDĚKOVÁ, A. LUKEŠOVÁ, K. ZÍTKA, O. CERNEI, N. MAREŠ, P. POHANKA, M. ADAM, V. BABULA, P. BEKLOVÁ, M. ZEMAN, L. KIZEK, R.

Original Title

Investigating the influence of taurine on thiol antioxidant status in Wistar rats with a multi-analytical approach

Type

journal article in Web of Science

Language

English

Original Abstract

Taurine (2-aminoethanesulfonic acid) is an organic acid widely distributed in animal tissues. It is involved in many physiological processes. Thus, it is widely discussed especially due to its antioxidant properties. In this study, we focused on the effect of taurine supplementation on the concentration of antioxidants in blood plasma and erythrocytes of Wistar rats. Taurine was applied in feed mixture in the dosage of 0, 1, 250, 500, 750, 1000, 1500, 2000, 2500, 3000, 3500 and 4000 mg/kg. We monitored both enzymatic and non-enzymatic antioxidants - glutathione peroxidase, glutathione reductase, and superoxide dismutase and reduced/oxidized glutathione and metallothionein. Using three different methods 2,2'-azino-bis(3-ethylbenzothiazoline-6-sulfonic acid (ABTS), Ferric Reducing Antioxidant Power (FRAP) and free radicals, we determined antioxidant capacity. In addition, we monitored levels of uric acid and glucose. Our results revealed significant changes in both enzymatic and non-enzymatic parameters with the increasing taurine supplementation. (C) 2013 Faculty of Health and Social Studies, University of South Bohemia in Ceske Budejovice. Published by Elsevier Urban & Partner Sp. z o.o. All rights reserved.

Keywords

Taurine; Thiol antioxidant; Oxidative stress; Glutathione; Metallothionein; Wistar rats

Authors

SOCHOR, J.; NEJDL, L.; RUTTKAY-NEDECKÝ, B.; BEZDĚKOVÁ, A.; LUKEŠOVÁ, K.; ZÍTKA, O.; CERNEI, N.; MAREŠ, P.; POHANKA, M.; ADAM, V.; BABULA, P.; BEKLOVÁ, M.; ZEMAN, L.; KIZEK, R.

RIV year

2014

Released

1. 4. 2014

Publisher

UNIV SOUTH BOHEMIA, FAC HEALTH & SOCIAL STUD, JIROVCOVA, CESKA BUDEJOVICE, 370 04, CZECH REPUBLIC

Location

CESKA BUDEJOVICE, 370 04, CZECH REPUBLIC

ISBN

1214-021X

Periodical

J APPL BIOMED

Year of study

12

Number

2

State

Czech Republic

Pages from

97

Pages to

110

Pages count

14

URL

http://www.sciencedirect.com/science/article/pii/S1214021X13000094

BibTex

@article{BUT112150,
  author="Jiří {Sochor} and Lukáš {Nejdl} and Branislav {Ruttkay-Nedecký} and Andrea {Bezděková} and Kateřina {Lukešová} and Ondřej {Zítka} and Natalia Vladimirovna {Cernei} and Petr {Mareš} and Miroslav {Pohanka} and Vojtěch {Adam} and Petr {Babula} and Miroslava {Beklová} and Ladislav {Zeman} and René {Kizek}",
  title="Investigating the influence of taurine on thiol antioxidant status in Wistar rats with a multi-analytical approach",
  journal="J APPL BIOMED",
  year="2014",
  volume="12",
  number="2",
  pages="97--110",
  doi="10.1016/j.jab.2013.01.002",
  issn="1214-021X",
  url="http://www.sciencedirect.com/science/article/pii/S1214021X13000094"
}