Publication detail

KRAS NF-jB is involved in the development of zinc resistance and reduced curability in prostate cancer

HOLUBOVÁ, M. AXMANOVÁ, M. GUMULEC, J. RAUDENSKÁ, M. SZTALMACHOVÁ, M. BABULA, P. ADAM, V. KIZEK, R. MASAŘÍK, M.

Original Title

KRAS NF-jB is involved in the development of zinc resistance and reduced curability in prostate cancer

Type

journal article in Web of Science

Language

English

Original Abstract

Zinc(II) ions are important components of many proteins and are involved in numerous cellular processes such as apoptosis or drug resistance. Prostate cancer has a unique relationship with zinc(II) ions. However, the relationship was examined only in short-term zinc(II) treatments. Therefore, the aim of this study was to create zinc-resistant prostatic cell lines at various stages of the disease (22Rv1 and PC-3) and a normal prostate epithelium (PNT1A) using a long-term zinc exposure.

Keywords

CITRATE METABOLISM; EPITHELIAL-CELLS; CARCINOMA-CELLS; DNA-DAMAGE; T-ANTIGEN; EXPRESSION; METALLOTHIONEIN; TRANSPORTER; APOPTOSIS; GENES

Authors

HOLUBOVÁ, M.; AXMANOVÁ, M.; GUMULEC, J.; RAUDENSKÁ, M.; SZTALMACHOVÁ, M.; BABULA, P.; ADAM, V.; KIZEK, R.; MASAŘÍK, M.

RIV year

2014

Released

1. 7. 2014

ISBN

1756-5901

Periodical

METALLOMICS

Year of study

6

Number

7

State

United Kingdom of Great Britain and Northern Ireland

Pages from

1240

Pages to

1253

Pages count

14

BibTex

@article{BUT111196,
  author="Monika {Kratochvílová} and Martina {Axmanová} and Jaromír {Gumulec} and Martina {Raudenská} and Markéta {Svobodová} and Petr {Babula} and Vojtěch {Adam} and René {Kizek} and Michal {Masařík}",
  title="KRAS NF-jB is involved in the development of zinc resistance and reduced curability in prostate cancer",
  journal="METALLOMICS",
  year="2014",
  volume="6",
  number="7",
  pages="1240--1253",
  doi="10.1039/c4mt00065j",
  issn="1756-5901"
}