Publication detail

Synthesis, biological, anti-inflammatory activities and quantum chemical calculation of some [4-(2, 4, 6-trimethylphenyl)-1(2H)-oxophthalazin-2yl] acetic acid hydrazide derivatives

EL-SHAMY, I. ABDEL-LATTIF, A. AL MAHMOUD ALSHEIKH, A. FOUDA, M. ELDEYAB, S. EL-HASHASH, M. JANČÁŘ, J.

Original Title

Synthesis, biological, anti-inflammatory activities and quantum chemical calculation of some [4-(2, 4, 6-trimethylphenyl)-1(2H)-oxophthalazin-2yl] acetic acid hydrazide derivatives

Type

journal article in Web of Science

Language

English

Original Abstract

The phthalazine carbohydrazide 2 was prepared and incorporated into the corresponding 1,2,4-triazole and carbamate derivatives. Phthalazine carboxylic acid hydrazide 2 was treated with isatine and cyclohexanone to give the corresponding hydrazone derivatives 16, 19 in good yields. Furthermore, a-amino acid derivative conjugated with 1-oxophthalazine moiety 35 was synthesized by the reaction of the corresponding aizde 28, via the azide-coupling method, with glycine methyl ester. The peptide ester 35 was converted into their orresponding amide 36 by treating with methanolic ammonia. Moreover, 35 was boiled with hydrazine hydrate to afford the corresponding hydrazide 37. Finally, the dipeptide 38 was prepared by coupling of 35 with L-alanine methyl ester. Some of these compounds were screened in vitro for their antimicrobial activity. The energy gap between the highest occupied molecular orbital and lowest unoccupied molecular orbital has been calculated using the theoretical computations to reflect the chemical reactivity and kinetic stability of compounds.

Keywords

Synthesis, Phthalazine, Quantum calculation, Carbohydrazide, Biological, Anti-inflammatory activities

Authors

EL-SHAMY, I.; ABDEL-LATTIF, A.; AL MAHMOUD ALSHEIKH, A.; FOUDA, M.; ELDEYAB, S.; EL-HASHASH, M.; JANČÁŘ, J.

RIV year

2015

Released

15. 2. 2015

ISBN

0143-7208

Periodical

DYES AND PIGMENTS

Year of study

113

Number

357

State

United Kingdom of Great Britain and Northern Ireland

Pages from

357

Pages to

371

Pages count

15

BibTex

@article{BUT109643,
  author="Ibrahim E. {El-Shamy} and Abdelmohsen Moustafa {Abdellatif} and Amer {Al Mahmoud Alsheikh} and Moustafa {Fouda} and Salam {Eldeyab} and Mather {El-hashash} and Josef {Jančář}",
  title="Synthesis, biological, anti-inflammatory activities and quantum chemical calculation of some [4-(2, 4, 6-trimethylphenyl)-1(2H)-oxophthalazin-2yl] acetic acid hydrazide derivatives",
  journal="DYES AND PIGMENTS",
  year="2015",
  volume="113",
  number="357",
  pages="357--371",
  doi="10.1016/j.dyepig.2014.08.026",
  issn="0143-7208"
}