Analysis of thermal effects in endoscopis nanocarriers-based Photodynamic Therapy applied to esophageal diseases

conference paper

English

In this work we propose a predictive model that allows the study of thermal effects produced when the optical radiation interacts with an esophageal or stomach disease with gold nanoparticles embedded. The model takes into account light distribution in the tumor tissue by means of a Monte Carlo method. Mie theory is used to obtain the gold nanoparticles optical properties and the thermal model employed is based on the bio-heat equation. The complete model was applied to two types of tumoral tissue (squamous cell carcinoma located in the esophagus and adenocarcinoma in the stomach) in order to study the thermal effects induced by the inclusion of gold nanoparticles.

esophageal tumor; photodynamic therapy; gold nanoparticles; photo-thermal interaction; endoscopic PDT

SALAS-GARCÍA, I.; FANJUL-VÉLEZ, F.; ORTEGA-QUIJANO, N.; WILFERT, O.; HUDCOVÁ, L.; POLIAK, J.; BARCÍK, P.

2014

4. 2. 2014

SPIE

Bellingham

978-0-8194-9854-0

Proc. SPIE 8941, Optical Interactions with Tissue and Cells XXV; and Terahertz for Biomedical Applications

15

16

84910C-1

89410C-6

6